General Information:

Id: 4,598 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: He J et al.(2010) Minireview: Nuclear receptor-controlled steroid hormone synthesis and metabolism Mol. Endocrinol. 1: 11-21 [PMID: 19762543]

Interaction Information:

Comment The PPAR family is composed of three isotypes: alpha, beta/delta, and gamma. PPAR-alpha is known for its function in the regulation of lipid and fatty acid metabolism. PPAR-gamma has an important role in adipogenesis and glucose homeostasis. PPAR-beta/delta plays diverse roles in cell differentiation and survival, and fatty acid metabolism. All three PPARs are expressed in the ovary and testis. The synthetic PPAR-gamma ligands thiazolidinediones (TZDs) can stimulate or inhibit the production of progesterone and estradiol in granulose cells, depending on the species and the status of the granulose cell differentiation.
Formal Description
Interaction-ID: 45898

drug/chemical compound

Thiazolidinedione

affects_quantity of

drug/chemical compound

Estradiol

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