General Information:

Id: 457 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: de la Monte SM(2009) Insulin resistance and Alzheimers disease BMB Rep 42: 475-481 [PMID: 19712582]

Interaction Information:

Comment Abeta accumulations can promote tau hyper-phosphorylation and formation of dementia associated paired helical filament-containing neuronal cytoskeletal lesions (neurofibrillary tangles, neuritic plaques, and neuropil threads) via functional impairment of the insulin signaling cascade, and attendant increased levels of GSK-3beta activity.
Formal Description
Interaction-ID: 2084

gene/protein

Amyloid beta peptide

increases_activity of

phenotype

neuronal cytoskeletal lesion