General Information:

Id: 457 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: de la Monte SM(2009) Insulin resistance and Alzheimers disease BMB Rep 42: 475-481 [PMID: 19712582]

Interaction Information:

Comment Abeta can adversely affect insulin signaling by competing with and inhibiting insulin binding or reducing the affinity of insulin binding to its own receptor.
Formal Description
Interaction-ID: 2082

gene/protein

Amyloid beta peptide

affects_activity of

Comment Abeta accumulations can promote tau hyper-phosphorylation and formation of dementia associated paired helical filament-containing neuronal cytoskeletal lesions (neurofibrillary tangles, neuritic plaques, and neuropil threads) via functional impairment of the insulin signaling cascade, and attendant increased levels of GSK-3beta activity.
Formal Description
Interaction-ID: 2083

gene/protein

Amyloid beta peptide

increases_quantity of

protein modification

MAPT-hyperphos

Comment Abeta accumulations can promote tau hyper-phosphorylation and formation of dementia associated paired helical filament-containing neuronal cytoskeletal lesions (neurofibrillary tangles, neuritic plaques, and neuropil threads) via functional impairment of the insulin signaling cascade, and attendant increased levels of GSK-3beta activity.
Formal Description
Interaction-ID: 2084

gene/protein

Amyloid beta peptide

increases_activity of

phenotype

neuronal cytoskeletal lesion

Comment In Alzheimer disease increased levels of Abeta are associated with reduced levels of CNS insulin and IGF-1.
Formal Description
Interaction-ID: 2091

gene/protein

Amyloid beta peptide

affects_quantity of

complex/PPI

Insulin

in CNS; if levels of APP / Amyloid beta peptide in AD are increased then level of insulin is reduced
Comment Insulin influences Abeta peptide metabolism by accelerating its trafficking to the plasma membrane from the trans-Golgi network, where it's generated and increases extracellular levels of Abeta by promoting its secretion and inhibiting its degradation by insulin-degrading enzyme.
Formal Description
Interaction-ID: 12996

complex/PPI

Insulin

increases_transport of

gene/protein

Amyloid beta peptide

from the trans-Golgi-network to the plasma membrane
Comment Abeta accumulations can promote tau hyper-phosphorylation and formation of dementia associated paired helical filament-containing neuronal cytoskeletal lesions (neurofibrillary tangles, neuritic plaques, and neuropil threads) via functional impairment of the insulin signaling cascade, and attendant increased levels of GSK-3beta activity.
Formal Description
Interaction-ID: 14606

gene/protein

Amyloid beta peptide

increases_quantity of

protein modification

MAPT-hyperphos