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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	457 (click here to show other Interactions for entry)
Diseases:	Alzheimer disease - [OMIM]
Organism:	Mammalia
Publication type:	review
Reference:	de la Monte SM(2009) Insulin resistance and Alzheimers disease BMB Rep 42: 475-481 [PMID: 19712582]

Interaction Information:

Comment	Inhibition of insulin/IGF-1 signaling blocks the Wnt pathway, which negatively regulates GSK-3beta via a PI3K/Akt-independent mechanism. In AD, both PI3K/Akt and Wnt signaling have been linked to key molecular abnormalities in AD.
Formal Description Interaction-ID: 2073	process canonical Wnt signaling pathway affects_activity of disease Alzheimer disease

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