General Information:

Id: 457 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: de la Monte SM(2009) Insulin resistance and Alzheimers disease BMB Rep 42: 475-481 [PMID: 19712582]

Interaction Information:

Comment Impairments in ligand-receptor binding and downstream signaling through insulin/IGF/IRS pathways, together are sufficient to cause brain insuIin/IGF resistance in AD.
Formal Description
Interaction-ID: 2068

affects_activity of

Comment Abeta can adversely affect insulin signaling by competing with and inhibiting insulin binding or reducing the affinity of insulin binding to its own receptor.
Formal Description
Interaction-ID: 2082

gene/protein

Amyloid beta peptide

affects_activity of