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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	457 (click here to show other Interactions for entry)
Diseases:	Alzheimer disease - [OMIM]
Organism:	Mammalia
Publication type:	review
Reference:	de la Monte SM(2009) Insulin resistance and Alzheimers disease BMB Rep 42: 475-481 [PMID: 19712582]

Interaction Information:

Comment	Impairments in ligand-receptor binding and downstream signaling through insulin/IGF/IRS pathways, together are sufficient to cause brain insuIin/IGF resistance in AD.
Formal Description Interaction-ID: 2068	process insulin receptor signaling pathway affects_activity of disease Alzheimer disease

Comment	Abeta can adversely affect insulin signaling by competing with and inhibiting insulin binding or reducing the affinity of insulin binding to its own receptor.
Formal Description Interaction-ID: 2082	gene/protein Amyloid beta peptide affects_activity of process insulin receptor signaling pathway

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