General Information:

Id: 457 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: de la Monte SM(2009) Insulin resistance and Alzheimers disease BMB Rep 42: 475-481 [PMID: 19712582]

Interaction Information:

Comment Insulin influences Abeta peptide metabolism by accelerating its trafficking to the plasma membrane from the trans-Golgi network, where it's generated and increases extracellular levels of Abeta by promoting its secretion and inhibiting its degradation by insulin-degrading enzyme.
Formal Description
Interaction-ID: 12996

complex/PPI

Insulin

increases_transport of

gene/protein

Amyloid beta peptide

from the trans-Golgi-network to the plasma membrane