General Information:

Id: 453
Diseases: Neurological
Mammalia
article
Reference: Alegre-Abarrategui J and Wade-Martins R(2009) Parkinson disease, LRRK2 and the endocytic-autophagic pathway. Autophagy 5: 1208-1210 [PMID: 19770575]

Interaction Information:

Comment RNAi-induced knockdown of LRRK2 increases autophagic activity.
Formal Description
Interaction-ID: 2008

gene/protein

LRRK2

affects_activity of

process

autophagy

Comment Expression of the R1441C mutant form of LRRK2 induces a cellular phenotype of impaired autophagic balance.
Formal Description
Interaction-ID: 2009

gene/protein mutant

LRRK2-p.R1441C

decreases_activity of

process

autophagy