General Information:

Id: 4,520
Diseases: Diabetes mellitus
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
Reference: Genua M et al.(2009) c-Abl and insulin receptor signalling Vitam. Horm. 80: 77-105 [PMID: 19251035]

Interaction Information:

Comment Inhibition of c-Abl tyrosine kinase by STI571 attenuates the effect of insulin on Akt/GSK-3beta phosphorylation and glycogen synthesis, and at the same time, it enhances the effect of insulin on ERK activation, cell proliferation and migration. This effect of STI571 is specific to c-Abl inhibition, because it does not occur in Abl-null cells and is restored in c-Abl-reconstituted cells.
Formal Description
Interaction-ID: 45130



affects_activity of

Drugbank entries Show/Hide entries for ABL1