General Information:

Id: 448 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Drosophila melanogaster
BTO:0000142 brain
article
Reference: Imai Y et al.(2008) Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila EMBO J. 27: 2432-2443 [PMID: 18701920]

Interaction Information:

Comment dLRRK regulates dopaminergic neuron function and maintenance. In animals expressing dLRRK mutants, known to be pathogenic in human, a significant reduction of DA neurons has been observed.
Formal Description
Interaction-ID: 1981

gene/protein

LRRK2

affects_activity of

process

neuron death

Comment dLRRK regulates dopaminergic neuron function and maintenance. In animals expressing dLRRK mutants, known to be pathogenic in human, a significant reduction of DA neurons has been observed.
Formal Description
Interaction-ID: 1986

gene/protein mutant

LRRK2-mut

increases_activity of

process

neuron death