General Information:

Id: 4,462 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Liu C et al.(2007) Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism Nature 7143: 477-481 [PMID: 17476214]

Interaction Information:

Comment Analysis of PGC-1alpha mRNA levels in mouse liver revealed a diurnal rhythm that peaks at CT13 (CT0 is the onset at hour 0 of subjective light period), gradually declines thereafter, and reaches a nadir at CT1. PGC-1alpha expression is similarly rhythmic in skeletal muscle, though to a lesser degree. The expression of other PGC-1 coactivators, that is, PGC-1beta and PRC, also show circadian rhythms in these tissues.
Formal Description
Interaction-ID: 45352

affects_expression of

gene/protein

PPARGC1A

in liver, in skeletal muscle
Comment Analysis of PGC-1alpha mRNA levels in mouse liver revealed a diurnal rhythm that peaks at CT13 (CT0 is the onset at hour 0 of subjective light period), gradually declines thereafter, and reaches a nadir at CT1. PGC-1alpha expression is similarly rhythmic in skeletal muscle, though to a lesser degree. The expression of other PGC-1 coactivators, that is, PGC-1beta and PRC, also show circadian rhythms in these tissues.
Formal Description
Interaction-ID: 45357

affects_expression of

gene/protein

PPARGC1B

in liver, in skeletal muscle
Comment Analysis of PGC-1alpha mRNA levels in mouse liver revealed a diurnal rhythm that peaks at CT13 (CT0 is the onset at hour 0 of subjective light period), gradually declines thereafter, and reaches a nadir at CT1. PGC-1alpha expression is similarly rhythmic in skeletal muscle, though to a lesser degree. The expression of other PGC-1 coactivators, that is, PGC-1beta and PRC, also show circadian rhythms in these tissues.
Formal Description
Interaction-ID: 45358

affects_expression of

gene/protein

PPRC1

in liver, in skeletal muscle
Comment PGC-1alpha regulates locomotor behaviour in mice and is required for maintaining normal circadian periods.
Formal Description
Interaction-ID: 45362

gene/protein

PPARGC1A

affects_activity of

Comment PEPCK (PCK1), a rate-limiting enzyme of hepatic gluconeogenesis, shows a daily cycle that peaks at CT13 in the wild-type liver. PGC-1alpha seems to be dispensable for the rhythmic expression of this enzyme. Nevertheless, the mRNA levels of PEPCK are constitutively elevated at CT1 and CT13, in a similar way to the previous studies. Pyruvate dehydrogenase kinase 4 (PDK4) is a key regulator of the pyruvate dehydrogenase complex that controls the flux of pyruvate into the tricarboxylic acid cycle. The diurnal PDK4 expression is severely impaired in PGC-1alpha-deficient liver and skeletal muscle, although the phase of PDK4 oscillation seems to be preserved. Similarly, the cyclic expression of fatty acid binding protein 3 (Fabp3/H-FABP) as well as other mitochondrial genes involved in oxidative phosphorylation (OXPHOS), such as aconitase (Aco2) and Cox4a (Cox4i1), is also disrupted in PGC-1alpha null skeletal muscle. Together, the results illustrate that PGC-1alpha is essential for oscillatory expression of clock and metabolic genes in vivo.
Formal Description
Interaction-ID: 45364

affects_expression of

gene/protein

PCK1

in liver; independent of PPARGC1A
Drugbank entries Show/Hide entries for PCK1
Comment PEPCK (PCK1), a rate-limiting enzyme of hepatic gluconeogenesis, shows a daily cycle that peaks at CT13 in the wild-type liver. PGC-1alpha seems to be dispensable for the rhythmic expression of this enzyme. Nevertheless, the mRNA levels of PEPCK are constitutively elevated at CT1 and CT13, in a similar way to the previous studies. Pyruvate dehydrogenase kinase 4 (PDK4) is a key regulator of the pyruvate dehydrogenase complex that controls the flux of pyruvate into the tricarboxylic acid cycle. The diurnal PDK4 expression is severely impaired in PGC-1alpha-deficient liver and skeletal muscle, although the phase of PDK4 oscillation seems to be preserved. Similarly, the cyclic expression of fatty acid binding protein 3 (Fabp3/H-FABP) as well as other mitochondrial genes involved in oxidative phosphorylation (OXPHOS), such as aconitase (Aco2) and Cox4a (Cox4i1), is also disrupted in PGC-1alpha null skeletal muscle. Together, the results illustrate that PGC-1alpha is essential for oscillatory expression of clock and metabolic genes in vivo.
Formal Description
Interaction-ID: 45365

affects_expression of

gene/protein

PDK4

via PPARGC1A
Drugbank entries Show/Hide entries for PDK4
Comment PEPCK (PCK1), a rate-limiting enzyme of hepatic gluconeogenesis, shows a daily cycle that peaks at CT13 in the wild-type liver. PGC-1alpha seems to be dispensable for the rhythmic expression of this enzyme. Nevertheless, the mRNA levels of PEPCK are constitutively elevated at CT1 and CT13, in a similar way to the previous studies. Pyruvate dehydrogenase kinase 4 (PDK4) is a key regulator of the pyruvate dehydrogenase complex that controls the flux of pyruvate into the tricarboxylic acid cycle. The diurnal PDK4 expression is severely impaired in PGC-1alpha-deficient liver and skeletal muscle, although the phase of PDK4 oscillation seems to be preserved. Similarly, the cyclic expression of fatty acid binding protein 3 (Fabp3/H-FABP) as well as other mitochondrial genes involved in oxidative phosphorylation (OXPHOS), such as aconitase (Aco2) and Cox4a (Cox4i1), is also disrupted in PGC-1alpha null skeletal muscle. Together, the results illustrate that PGC-1alpha is essential for oscillatory expression of clock and metabolic genes in vivo.
Formal Description
Interaction-ID: 45366

affects_expression of

gene/protein

FABP3

via PPARGC1A
Comment PEPCK (PCK1), a rate-limiting enzyme of hepatic gluconeogenesis, shows a daily cycle that peaks at CT13 in the wild-type liver. PGC-1alpha seems to be dispensable for the rhythmic expression of this enzyme. Nevertheless, the mRNA levels of PEPCK are constitutively elevated at CT1 and CT13, in a similar way to the previous studies. Pyruvate dehydrogenase kinase 4 (PDK4) is a key regulator of the pyruvate dehydrogenase complex that controls the flux of pyruvate into the tricarboxylic acid cycle. The diurnal PDK4 expression is severely impaired in PGC-1alpha-deficient liver and skeletal muscle, although the phase of PDK4 oscillation seems to be preserved. Similarly, the cyclic expression of fatty acid binding protein 3 (Fabp3/H-FABP) as well as other mitochondrial genes involved in oxidative phosphorylation (OXPHOS), such as aconitase (Aco2) and Cox4a (Cox4i1), is also disrupted in PGC-1alpha null skeletal muscle. Together, the results illustrate that PGC-1alpha is essential for oscillatory expression of clock and metabolic genes in vivo.
Formal Description
Interaction-ID: 45367

affects_expression of

gene/protein

ACO2

via PPARGC1A
Drugbank entries Show/Hide entries for ACO2
Comment PEPCK (PCK1), a rate-limiting enzyme of hepatic gluconeogenesis, shows a daily cycle that peaks at CT13 in the wild-type liver. PGC-1alpha seems to be dispensable for the rhythmic expression of this enzyme. Nevertheless, the mRNA levels of PEPCK are constitutively elevated at CT1 and CT13, in a similar way to the previous studies. Pyruvate dehydrogenase kinase 4 (PDK4) is a key regulator of the pyruvate dehydrogenase complex that controls the flux of pyruvate into the tricarboxylic acid cycle. The diurnal PDK4 expression is severely impaired in PGC-1alpha-deficient liver and skeletal muscle, although the phase of PDK4 oscillation seems to be preserved. Similarly, the cyclic expression of fatty acid binding protein 3 (Fabp3/H-FABP) as well as other mitochondrial genes involved in oxidative phosphorylation (OXPHOS), such as aconitase (Aco2) and Cox4a (Cox4i1), is also disrupted in PGC-1alpha null skeletal muscle. Together, the results illustrate that PGC-1alpha is essential for oscillatory expression of clock and metabolic genes in vivo.
Formal Description
Interaction-ID: 45368

affects_expression of

gene/protein

COX4I1

via PPARGC1A
Drugbank entries Show/Hide entries for COX4I1
Comment PEPCK (PCK1), a rate-limiting enzyme of hepatic gluconeogenesis, shows a daily cycle that peaks at CT13 in the wild-type liver. PGC-1alpha seems to be dispensable for the rhythmic expression of this enzyme. Nevertheless, the mRNA levels of PEPCK are constitutively elevated at CT1 and CT13, in a similar way to the previous studies. Pyruvate dehydrogenase kinase 4 (PDK4) is a key regulator of the pyruvate dehydrogenase complex that controls the flux of pyruvate into the tricarboxylic acid cycle. The diurnal PDK4 expression is severely impaired in PGC-1alpha-deficient liver and skeletal muscle, although the phase of PDK4 oscillation seems to be preserved. Similarly, the cyclic expression of fatty acid binding protein 3 (Fabp3/H-FABP) as well as other mitochondrial genes involved in oxidative phosphorylation (OXPHOS), such as aconitase (Aco2) and Cox4a (Cox4i1), is also disrupted in PGC-1alpha null skeletal muscle. Together, the results illustrate that PGC-1alpha is essential for oscillatory expression of clock and metabolic genes in vivo.
Formal Description
Interaction-ID: 45369

affects_activity of

process

gluconeogenesis

via PCK1
Comment PEPCK (PCK1), a rate-limiting enzyme of hepatic gluconeogenesis, shows a daily cycle that peaks at CT13 in the wild-type liver. PGC-1alpha seems to be dispensable for the rhythmic expression of this enzyme. Nevertheless, the mRNA levels of PEPCK are constitutively elevated at CT1 and CT13, in a similar way to the previous studies. Pyruvate dehydrogenase kinase 4 (PDK4) is a key regulator of the pyruvate dehydrogenase complex that controls the flux of pyruvate into the tricarboxylic acid cycle. The diurnal PDK4 expression is severely impaired in PGC-1alpha-deficient liver and skeletal muscle, although the phase of PDK4 oscillation seems to be preserved. Similarly, the cyclic expression of fatty acid binding protein 3 (Fabp3/H-FABP) as well as other mitochondrial genes involved in oxidative phosphorylation (OXPHOS), such as aconitase (Aco2) and Cox4a (Cox4i1), is also disrupted in PGC-1alpha null skeletal muscle. Together, the results illustrate that PGC-1alpha is essential for oscillatory expression of clock and metabolic genes in vivo.
Formal Description
Interaction-ID: 45370

affects_activity of

complex/PPI

Pyruvate dehydrogenase complex

via PPARGC1A and PDK4
Comment PEPCK (PCK1), a rate-limiting enzyme of hepatic gluconeogenesis, shows a daily cycle that peaks at CT13 in the wild-type liver. PGC-1alpha seems to be dispensable for the rhythmic expression of this enzyme. Nevertheless, the mRNA levels of PEPCK are constitutively elevated at CT1 and CT13, in a similar way to the previous studies. Pyruvate dehydrogenase kinase 4 (PDK4) is a key regulator of the pyruvate dehydrogenase complex that controls the flux of pyruvate into the tricarboxylic acid cycle. The diurnal PDK4 expression is severely impaired in PGC-1alpha-deficient liver and skeletal muscle, although the phase of PDK4 oscillation seems to be preserved. Similarly, the cyclic expression of fatty acid binding protein 3 (Fabp3/H-FABP) as well as other mitochondrial genes involved in oxidative phosphorylation (OXPHOS), such as aconitase (Aco2) and Cox4a (Cox4i1), is also disrupted in PGC-1alpha null skeletal muscle. Together, the results illustrate that PGC-1alpha is essential for oscillatory expression of clock and metabolic genes in vivo.
Formal Description
Interaction-ID: 45373

affects_activity of

via PPARGC1A, ACO2, and COX4I1