General Information:

Id: 4,443
Diseases: Metabolic
Mammalia
article
Reference: Simons M et al.(1998) Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons Proc. Natl. Acad. Sci. U.S.A. 95: 6460-6464 [PMID: 9600988]

Interaction Information:

Comment Lovastatin in the presence of low amounts of mevalonate inhibits cholesterol biosynthesis.
Formal Description
Interaction-ID: 44920

drug/chemical compound

Lovastatin

decreases_quantity of

drug/chemical compound

Cholesterol

Drugbank entries Show/Hide entries for Lovastatin or Cholesterol
Comment Cholesterol-depletion interferes with the beta-cleavage of APP. Cholesterol depletion inhibits production and secretion of A-beta in hippocampal neurons.
Formal Description
Interaction-ID: 44927

drug/chemical compound

Cholesterol

increases_quantity of

gene/protein

Amyloid beta peptide

Drugbank entries Show/Hide entries for Cholesterol