General Information:

Id: 4,409 (click here to show other Interactions for entry)
Diseases: Metabolic
Rattus norvegicus
article/cited
Reference: Ma T et al.(2011) Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3 J. Neurosci. 31 [PMID: 22131415]

Interaction Information:

Comment GSK3 is a component of the destruction complex which is best known as a regulator of beta-catenin levels and is disrupted by activation of the canonical Wnt pathway. Previous work indicates that this pool of GSK3 regulates mTOR, by maintaining high activity of the mTOR suppressor TSC2 (which also is a component of the destruction complex). (cited information)
Formal Description
Interaction-ID: 44924

decreases_activity of

complex/PPI

Beta-catenin destruction complex

if the canonical pathway is activated;