CIDeRGeneral Information:
| Id: | 4,409 (click here to show other Interactions for entry) |
| Diseases: |
Metabolic
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| Rattus norvegicus | |
| article/cited | |
| Reference: | Ma T et al.(2011) Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3 J. Neurosci. 31 [PMID: 22131415] |
Interaction Information:
| Comment | Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of GSK3. MTOR is tonically suppressed in rat hippocampus under resting conditions, a consequence of the basal activity of glycogen synthetase kinase 3 (GSK3). |
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Formal Description Interaction-ID: 44811 |
process increases_activity of gene/protein |
| Drugbank entries | Show/Hide entries for MTOR |
| Comment | mTOR is regulated by a canonical pathway that includes phosphatidylinositol-3-kinase (PI3K), phosphoinositide-dependent protein kinase 1 (PDK1), and Akt. (cited information) |
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Formal Description Interaction-ID: 44817 |
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| Drugbank entries | Show/Hide entries for MTOR |
| Comment | GSK3 is a tonic suppressor of mTOR and is regulated by the Wnt signaling pathway. (cited information) |
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Formal Description Interaction-ID: 44823 |
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| Drugbank entries | Show/Hide entries for GSK3B |
| Comment | GSK3 is a component of the destruction complex which is best known as a regulator of beta-catenin levels and is disrupted by activation of the canonical Wnt pathway. Previous work indicates that this pool of GSK3 regulates mTOR, by maintaining high activity of the mTOR suppressor TSC2 (which also is a component of the destruction complex). (cited information) |
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Formal Description Interaction-ID: 44924 |
process decreases_activity of complex/PPI Beta-catenin destruction complex |