General Information:

Id: 4,409 (click here to show other Interactions for entry)
Diseases: Metabolic
Rattus norvegicus
article/cited
Reference: Ma T et al.(2011) Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3 J. Neurosci. 31 [PMID: 22131415]

Interaction Information:

Comment Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of GSK3. MTOR is tonically suppressed in rat hippocampus under resting conditions, a consequence of the basal activity of glycogen synthetase kinase 3 (GSK3).
Formal Description
Interaction-ID: 44811

increases_activity of

gene/protein

MTOR

synaptic stimulation of mTOR is mediated by Wnt signaling
Drugbank entries Show/Hide entries for MTOR
Comment mTOR is regulated by a canonical pathway that includes phosphatidylinositol-3-kinase (PI3K), phosphoinositide-dependent protein kinase 1 (PDK1), and Akt. (cited information)
Formal Description
Interaction-ID: 44817

affects_activity of

gene/protein

MTOR

Drugbank entries Show/Hide entries for MTOR
Comment GSK3 is a tonic suppressor of mTOR and is regulated by the Wnt signaling pathway. (cited information)
Formal Description
Interaction-ID: 44823

affects_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment GSK3 is a component of the destruction complex which is best known as a regulator of beta-catenin levels and is disrupted by activation of the canonical Wnt pathway. Previous work indicates that this pool of GSK3 regulates mTOR, by maintaining high activity of the mTOR suppressor TSC2 (which also is a component of the destruction complex). (cited information)
Formal Description
Interaction-ID: 44924

decreases_activity of

complex/PPI

Beta-catenin destruction complex

if the canonical pathway is activated;