General Information:

Id: 4,407
Diseases: Metabolic
Mammalia
review
Reference: Chauvin B et al.(2013) Drug-Drug Interactions Between HMG-CoA Reductase Inhibitors (Statins) and Antiviral Protease Inhibitors Clin Pharmacokinet 52: 815-831 [PMID: 23703578]

Interaction Information:

Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44779

drug/chemical compound

Atorvastatin

interacts (colocalizes) with

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Atorvastatin or HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44786

drug/chemical compound

Atorvastatin

decreases_activity of

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Atorvastatin or HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44787

drug/chemical compound

Rosuvastatin

interacts (colocalizes) with

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Rosuvastatin or HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44788

drug/chemical compound

Rosuvastatin

decreases_activity of

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Rosuvastatin or HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44789

drug/chemical compound

Simvastatin

interacts (colocalizes) with

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Simvastatin or HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44790

drug/chemical compound

Simvastatin

decreases_activity of

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Simvastatin or HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44794

drug/chemical compound

Pitavastatin

interacts (colocalizes) with

gene/protein

HMGCR

Drugbank entries Show/Hide entries for HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44795

drug/chemical compound

Pitavastatin

decreases_activity of

gene/protein

HMGCR

Drugbank entries Show/Hide entries for HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44796

drug/chemical compound

Fluvastatin

interacts (colocalizes) with

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Fluvastatin or HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44797

drug/chemical compound

Fluvastatin

decreases_activity of

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Fluvastatin or HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44800

drug/chemical compound

Lovastatin

interacts (colocalizes) with

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Lovastatin or HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44801

drug/chemical compound

Lovastatin

decreases_activity of

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Lovastatin or HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44802

drug/chemical compound

Pravastatin

interacts (colocalizes) with

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Pravastatin or HMGCR
Comment All statins (e.g. atorvastatin, rosuvastatin, pitavastatin, fluvastatin, lovastatin, simvastatin, pravastatin) have a high affinity for HMG-CoA reductase and are therefore potent competitive inhibitors of this enzyme.
Formal Description
Interaction-ID: 44803

drug/chemical compound

Pravastatin

decreases_activity of

gene/protein

HMGCR

Drugbank entries Show/Hide entries for Pravastatin or HMGCR