General Information:

Id: 43 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Mus musculus
ToI-beta (for Tet-On delta-I-kappa-B in beta cells)
BTO:0000991 pancreatic islet
Reference: Eldor R et al.(2006) Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents Proc. Natl. Acad. Sci. U.S.A. 103: 5072-5077 [PMID: 16551748]

Interaction Information:

Comment Dox-treated beta cells were significantly more resistant to cytokine-induced apoptosis than the control.
Formal Description
Interaction-ID: 109

drug/chemical compound


decreases_activity of

Drugbank entries Show/Hide entries for Doxycycline
Comment Cytokine (Il-1-beta and IFN-gamma) treatment induced apoptosis in pancreatic islets.
Formal Description
Interaction-ID: 117



increases_activity of

Drugbank entries Show/Hide entries for IFNG