General Information:

Id: 4,392 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
Reference: Chaudhary A and Willett KL(2006) Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. Johns wort Toxicology 217: 194-205 [PMID: 16271822]

Interaction Information:

Comment CYP1B1 is involved in metabolizing both polycyclic aromatic hydrocarbons and estradiol to potentially carcinogenic intermediates, and it is also over-expressed in human cancer cells. In order to investigate whether flavonoids could specifically inhibit CYP1B1, seven flavonoids in St. John s wort and apigenin were screened for their inhibition of recombinant human CYP1B1 and CYP1A1. While seven flavonoids (myricetin, apigenin, kaempferol, quercetin, amentoflavone, quercitrin and rutin) were slightly more selective for CYP1B1 EROD inhibition compared to CYP1A1 the difference in K(i)s for the P450s were not significantly different. Rutin did not inhibit CYP1A1 at concentrations up to 10 microM. Kinetic analyses determined that apigenin and amentoflavone were competitive inhibitors of CYP1B1, while quercetin showed mixed type inhibition.
Formal Description
Interaction-ID: 44708

drug/chemical compound


decreases_activity of



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