General Information:

Id: 4,348 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Yuyun X et al.(2012) Effects of Low Concentrations of Rotenone upon Mitohormesis in SH-SY5Y Cells Dose Response 11: 270-280 [PMID: 23930106]

Interaction Information:

Comment Compared with the control group, reduced glutathione (GSH) and GSH/oxidized glutathione(GSSG) ratio levels were significantly increased at a low concentration of rotenone (12.5 nmol/L) which is of great relevance with respect to oxidative stress, whereas higher levels of rotenone suppressed GSH contents.
Formal Description
Interaction-ID: 44553

drug/chemical compound

Rotenone

increases_quantity of

drug/chemical compound

Glutathione

at a concentration of 12.5 nmol/L rotenone
Drugbank entries Show/Hide entries for
Comment Compared with the control group, reduced glutathione (GSH) and GSH/oxidized glutathione(GSSG) ratio levels were significantly increased at a low concentration of rotenone (12.5 nmol/L) which is of great relevance with respect to oxidative stress, whereas higher levels of rotenone suppressed GSH contents.
Formal Description
Interaction-ID: 44555

drug/chemical compound

Rotenone

decreases_quantity of

drug/chemical compound

Glutathione

if more than 12.5 nmol/L rotenone
Drugbank entries Show/Hide entries for