General Information:

Id: 4,348
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Yuyun X et al.(2012) Effects of Low Concentrations of Rotenone upon Mitohormesis in SH-SY5Y Cells Dose Response 11: 270-280 [PMID: 23930106]

Interaction Information:

Comment Compared with controls, rotenone (12.5 nmol/L) significantly increased the quantity of mitochondria and amount of oxygen consumption, whereas rotenone at more than 12.5 nmol/L decreased the quantity of mitochondria and amount of oxygen consumption.
Formal Description
Interaction-ID: 44448

drug/chemical compound

Rotenone

increases_quantity of

cellular component

mitochondrion

at a concentration of 12.5 nmol/L rotenone
Comment Compared with controls, rotenone (12.5 nmol/L) significantly increased the quantity of mitochondria and amount of oxygen consumption, whereas rotenone at more than 12.5 nmol/L decreased the quantity of mitochondria and amount of oxygen consumption.
Formal Description
Interaction-ID: 44449

drug/chemical compound

Rotenone

decreases_quantity of

cellular component

mitochondrion

if more than 12.5 nmol/L rotenone
Comment Compared with controls, rotenone (12.5 nmol/L) significantly increased the quantity of mitochondria and amount of oxygen consumption, whereas rotenone at more than 12.5 nmol/L decreased the quantity of mitochondria and amount of oxygen consumption.
Formal Description
Interaction-ID: 44450

drug/chemical compound

Rotenone

increases_activity of

at 12.5 nmol/L rotenone
Comment Compared with controls, rotenone (12.5 nmol/L) significantly increased the quantity of mitochondria and amount of oxygen consumption, whereas rotenone at more than 12.5 nmol/L decreased the quantity of mitochondria and amount of oxygen consumption.
Formal Description
Interaction-ID: 44451

drug/chemical compound

Rotenone

increases_activity of

if more than 12.5 nmol/L rotenone
Comment To test whether the mitochondrial biogenesis and improvement in mitochondrial function are related to SIRT1 and PGC-1alpha, rotenone impact on their expression was investigated. The expression of PGC-1alpha and SIRT1 increased at low concentrations of rotenone (12.5 and 25 nmol/L). SIRT1 demonstrated a 20% increase compared with control group, while PGC-1 alpha showed 26% increase. However, at higher concentrations (50 and 100 nmol/L), the expression of SIRT1 still increased (40% compared with the control group) but that of PGC-1alpha decreased to normal level.
Formal Description
Interaction-ID: 44452

drug/chemical compound

Rotenone

increases_expression of

gene/protein

PPARGC1A

at concentrations of 12.5 and 25 nmol/L rotenone
Comment To test whether the mitochondrial biogenesis and improvement in mitochondrial function are related to SIRT1 and PGC-1alpha, rotenone impact on their expression was investigated. The expression of PGC-1alpha and SIRT1 increased at low concentrations of rotenone (12.5 and 25 nmol/L). SIRT1 demonstrated a 20% increase compared with control group, while PGC-1 alpha showed 26% increase. However, at higher concentrations (50 and 100 nmol/L), the expression of SIRT1 still increased (40% compared with the control group) but that of PGC-1alpha decreased to normal level.
Formal Description
Interaction-ID: 44453

drug/chemical compound

Rotenone

increases_expression of

gene/protein

SIRT1

at concentrations of 12.5 and 25 nmol/L rotenone
Comment To test whether the mitochondrial biogenesis and improvement in mitochondrial function are related to SIRT1 and PGC-1alpha, rotenone impact on their expression was investigated. The expression of PGC-1alpha and SIRT1 increased at low concentrations of rotenone (12.5 and 25 nmol/L). SIRT1 demonstrated a 20% increase compared with control group, while PGC-1 alpha showed 26% increase. However, at higher concentrations (50 and 100 nmol/L), the expression of SIRT1 still increased (40% compared with the control group) but that of PGC-1alpha decreased to normal level.
Formal Description
Interaction-ID: 44454

drug/chemical compound

Rotenone

NOT increases_expression of

gene/protein

PPARGC1A

at concentrations of 50 and 100 nmol/L rotenone
Comment After rotenone treatment reactive oxygen species (ROS) levels increased significantly compared with the control group, and ROS levels increased in a dose-dependent manner.
Formal Description
Interaction-ID: 44455

drug/chemical compound

Rotenone

increases_quantity of

drug/chemical compound

Reactive oxygen species

Comment Compared with the control group, reduced glutathione (GSH) and GSH/oxidized glutathione(GSSG) ratio levels were significantly increased at a low concentration of rotenone (12.5 nmol/L) which is of great relevance with respect to oxidative stress, whereas higher levels of rotenone suppressed GSH contents.
Formal Description
Interaction-ID: 44553

drug/chemical compound

Rotenone

increases_quantity of

drug/chemical compound

Glutathione

at a concentration of 12.5 nmol/L rotenone
Drugbank entries Show/Hide entries for
Comment Compared with the control group, reduced glutathione (GSH) and GSH/oxidized glutathione(GSSG) ratio levels were significantly increased at a low concentration of rotenone (12.5 nmol/L) which is of great relevance with respect to oxidative stress, whereas higher levels of rotenone suppressed GSH contents.
Formal Description
Interaction-ID: 44555

drug/chemical compound

Rotenone

decreases_quantity of

drug/chemical compound

Glutathione

if more than 12.5 nmol/L rotenone
Drugbank entries Show/Hide entries for