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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	4,335 (click here to show other Interactions for entry)
Diseases:	Metabolic
Organism:	Rattus norvegicus
Tissue/Cell line:	BTO:0004318 WB-F344 cell
Publication type:	article
Reference:	Prochazkova J et al.(2011) The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors Toxicol. Sci. 122: 349-360 [PMID: 21602191]

Interaction Information:

Comment	Observed was an increased accumulation of downshifted/dephosphorylated Dvl2 and 3 forms, as early as 8 h after TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) addition, suggesting that, apart from beta-catenin downregulation, TCDD inhibits further proximate Wnt signaling events.
Formal Description Interaction-ID: 44472	drug/chemical compound 2,3,7,8-Tetrachlorodibenzodioxin decreases_activity of process canonical Wnt signaling pathway

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