General Information:

Id: 4,335 (click here to show other Interactions for entry)
Diseases: Metabolic
Rattus norvegicus
BTO:0004318 WB-F344 cell
article
Reference: Prochazkova J et al.(2011) The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors Toxicol. Sci. 122: 349-360 [PMID: 21602191]

Interaction Information:

Comment AhR and Wnt/beta-catenin cooperate in the induction of AhR transcriptional targets, such as Cyp1a1 and Cyp1b1. However, simultaneously, the activation of AhR led to a decrease of dephosphorylated active beta-catenin pool, as well as to hypophosphorylation of Dishevelled, participating in regulation of Wnt signaling.
Formal Description
Interaction-ID: 44356

increases_expression of

gene/protein

CYP1A1

the induction is supported by AHR
Comment AhR and Wnt/beta-catenin cooperate in the induction of AhR transcriptional targets, such as Cyp1a1 and Cyp1b1. However, simultaneously, the activation of AhR led to a decrease of dephosphorylated active beta-catenin pool, as well as to hypophosphorylation of Dishevelled, participating in regulation of Wnt signaling.
Formal Description
Interaction-ID: 44357

increases_expression of

gene/protein

CYP1B1

the induction is supported by AHR
Comment In WB-F344 cells, recombinant mouse Wnt3a (the ligand of the Wnt/b-catenin pathway) induced a rapid phosphorylation of LRP6 (the Wnt coreceptor), and the accumulation of the ABC form which is dephosphorylated on S37 and T41.
Formal Description
Interaction-ID: 44363

gene/protein

WNT3A

increases_activity of

Comment Persistent AhR activation reduces mRNA levels of Wnt/ beta-Catenin target genes, disrupts cytokeratin expression pattern, and downregulates expression of Kitl and Ncam1.
Formal Description
Interaction-ID: 44439

gene/protein

AHR

decreases_activity of

by reducing mRNA levels of Wnt/beta-Catenin target genes and disrupting cytokeratin expression pattern
Drugbank entries Show/Hide entries for AHR
Comment Observed was an increased accumulation of downshifted/dephosphorylated Dvl2 and 3 forms, as early as 8 h after TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) addition, suggesting that, apart from beta-catenin downregulation, TCDD inhibits further proximate Wnt signaling events.
Formal Description
Interaction-ID: 44472

drug/chemical compound

2,3,7,8-Tetrachlorodibenzodioxin

decreases_activity of