General Information:

Id: 4,335 (click here to show other Interactions for entry)
Diseases: Metabolic
Rattus norvegicus
BTO:0004318 WB-F344 cell
article
Reference: Prochazkova J et al.(2011) The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors Toxicol. Sci. 122: 349-360 [PMID: 21602191]

Interaction Information:

Comment AhR and Wnt/beta-catenin cooperate in the induction of AhR transcriptional targets, such as Cyp1a1 and Cyp1b1. However, simultaneously, the activation of AhR led to a decrease of dephosphorylated active beta-catenin pool, as well as to hypophosphorylation of Dishevelled, participating in regulation of Wnt signaling.
Formal Description
Interaction-ID: 44357

increases_expression of

gene/protein

CYP1B1

the induction is supported by AHR