General Information:

Id: 4,327 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Metabolic
Homo sapiens
article/cited
Reference: Salins P et al.(2007) Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling Neurosci. Lett. 412: 211-216 [PMID: 17234346]

Interaction Information:

Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cell.
Formal Description
Interaction-ID: 44287

drug/chemical compound

Lovastatin

decreases_activity of

in differentiated SK-NSH cells; by preventing apoptosis
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Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cell.
Formal Description
Interaction-ID: 44290

drug/chemical compound

Lovastatin

decreases_activity of

in differentiated SK-NSH cells
Drugbank entries Show/Hide entries for Lovastatin
Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cells, accompanied by reduction in active GSK3B, and increased nuclear translocation of beta-catenin, TCF-3, and LEF-1.
Formal Description
Interaction-ID: 44291

drug/chemical compound

Lovastatin

decreases_quantity of

protein modification

GSK3B -phos (activated)

Drugbank entries Show/Hide entries for Lovastatin
Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cells, accompanied by reduction in active GSK3B, and increased nuclear translocation of beta-catenin, TCF-3, and LEF-1.
Formal Description
Interaction-ID: 44292

drug/chemical compound

Lovastatin

increases_transport of

gene/protein

CTNNB1

(increased nuclear translocation of beta-catenin)
Drugbank entries Show/Hide entries for Lovastatin or CTNNB1
Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cells, accompanied by reduction in active GSK3B, and increased nuclear translocation of beta-catenin, TCF-3, and LEF-1.
Formal Description
Interaction-ID: 44293

drug/chemical compound

Lovastatin

increases_transport of

gene/protein

TCF3

(increased nuclear translocation of TCF-3)
Drugbank entries Show/Hide entries for Lovastatin
Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cells, accompanied by reduction in active GSK3B, and increased nuclear translocation of beta-catenin, TCF-3, and LEF-1.
Formal Description
Interaction-ID: 44294

drug/chemical compound

Lovastatin

increases_transport of

gene/protein

LEF1

(increased nuclear translocation of LEF-1)
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Comment Lovastatin could activate the transcription of Wnt related genes, some of which could be important for cell survival.
Formal Description
Interaction-ID: 44297

drug/chemical compound

Lovastatin

increases_expression of

gene/protein

Wnt-related gene

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Comment Beta-catenin and TCF were required for the neuroprotective function of lovastati.
Formal Description
Interaction-ID: 44305

gene/protein

CTNNB1

affects_activity of

drug/chemical compound

Lovastatin

concerning neuroprotective function
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Comment Beta-catenin and TCF were required for the neuroprotective function of lovastati.
Formal Description
Interaction-ID: 44306

gene/protein

TCF3

affects_activity of

drug/chemical compound

Lovastatin

concerning neuroprotective function
Drugbank entries Show/Hide entries for
Comment Lovastatin, a member of the statins, inactivates GSK3B resulting in induction of Wnt signaling. This may be the neuroprotective effect of lovastatin. (cited information)
Formal Description
Interaction-ID: 44737

drug/chemical compound

Lovastatin

decreases_activity of

gene/protein

GSK3B

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Comment Lovastatin could partially regulate beta-catenin expression by inhibiting the phosphorylated GSK3B activit.
Formal Description
Interaction-ID: 44743

drug/chemical compound

Lovastatin

affects_expression of

gene/protein

CTNNB1

by inhibiting the phosphorylated GSK3B activity
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Comment Lovastatin activates the Wnt signaling to reduce the effect of Abeta (42.
Formal Description
Interaction-ID: 44751

drug/chemical compound

Lovastatin

increases_activity of

to reduce the effect of Abeta (42)
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Comment Statins like lovastatin inhibit 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA), blocking thereby cholesterol biosynthesis.(cited information)
Formal Description
Interaction-ID: 44775

drug/chemical compound

Lovastatin

decreases_activity of

gene/protein

HMGCR

blocking thereby cholesterol biosynthesis
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Comment Lovastatin could partially regulate beta-catenin expression by inhibiting the phosphorylated GSK3B activity.
Formal Description
Interaction-ID: 45039

drug/chemical compound

Lovastatin

increases_activity of

gene/protein

CTNNB1

by inhibiting the phosphorylated GSK3B activity
Drugbank entries Show/Hide entries for Lovastatin or CTNNB1