General Information:

Id: 4,327 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Metabolic
Homo sapiens
article/cited
Reference: Salins P et al.(2007) Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling Neurosci. Lett. 412: 211-216 [PMID: 17234346]

Interaction Information:

Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cells, accompanied by reduction in active GSK3B, and increased nuclear translocation of beta-catenin, TCF-3, and LEF-1.
Formal Description
Interaction-ID: 44294

drug/chemical compound

Lovastatin

increases_transport of

gene/protein

LEF1

(increased nuclear translocation of LEF-1)
Drugbank entries Show/Hide entries for Lovastatin