General Information:

Id: 4,327
Diseases: Alzheimer disease - [OMIM]
Metabolic
Homo sapiens
article/cited
Reference: Salins P et al.(2007) Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling Neurosci. Lett. 412: 211-216 [PMID: 17234346]

Interaction Information:

Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cell.
Formal Description
Interaction-ID: 44287

drug/chemical compound

Lovastatin

decreases_activity of

in differentiated SK-NSH cells; by preventing apoptosis
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Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cell.
Formal Description
Interaction-ID: 44290

drug/chemical compound

Lovastatin

decreases_activity of

in differentiated SK-NSH cells
Drugbank entries Show/Hide entries for Lovastatin
Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cells, accompanied by reduction in active GSK3B, and increased nuclear translocation of beta-catenin, TCF-3, and LEF-1.
Formal Description
Interaction-ID: 44291

drug/chemical compound

Lovastatin

decreases_quantity of

protein modification

GSK3B -phos (activated)

Drugbank entries Show/Hide entries for Lovastatin
Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cells, accompanied by reduction in active GSK3B, and increased nuclear translocation of beta-catenin, TCF-3, and LEF-1.
Formal Description
Interaction-ID: 44292

drug/chemical compound

Lovastatin

increases_transport of

gene/protein

CTNNB1

(increased nuclear translocation of beta-catenin)
Drugbank entries Show/Hide entries for Lovastatin or CTNNB1
Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cells, accompanied by reduction in active GSK3B, and increased nuclear translocation of beta-catenin, TCF-3, and LEF-1.
Formal Description
Interaction-ID: 44293

drug/chemical compound

Lovastatin

increases_transport of

gene/protein

TCF3

(increased nuclear translocation of TCF-3)
Drugbank entries Show/Hide entries for Lovastatin
Comment Lovastatin prevented Abeta (42) -induced apoptosis in differentiated SK-NSH cells, accompanied by reduction in active GSK3B, and increased nuclear translocation of beta-catenin, TCF-3, and LEF-1.
Formal Description
Interaction-ID: 44294

drug/chemical compound

Lovastatin

increases_transport of

gene/protein

LEF1

(increased nuclear translocation of LEF-1)
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Comment Lovastatin could activate the transcription of Wnt related genes, some of which could be important for cell survival.
Formal Description
Interaction-ID: 44297

drug/chemical compound

Lovastatin

increases_expression of

gene/protein

Wnt-related gene

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Comment Beta-catenin and TCF were required for the neuroprotective function of lovastati.
Formal Description
Interaction-ID: 44305

gene/protein

CTNNB1

affects_activity of

drug/chemical compound

Lovastatin

concerning neuroprotective function
Drugbank entries Show/Hide entries for CTNNB1 or Lovastatin
Comment Beta-catenin and TCF were required for the neuroprotective function of lovastati.
Formal Description
Interaction-ID: 44306

gene/protein

TCF3

affects_activity of

drug/chemical compound

Lovastatin

concerning neuroprotective function
Drugbank entries Show/Hide entries for
Comment Hypothesis: Lovastatin inactivates GSK3B, leading to increase in beta-catenin level and formation of CTNNB1/TCF/LEF complex. This complex translocates to the nucleus, resulting in transcription of Wnt related prosurvival genes. Thus, the activation of GSK3B by Abeta (42) could be suppressed by lovastatin.
Formal Description
Interaction-ID: 44307

none selected

Drugbank entries Show/Hide entries for or
Comment Lovastatin, a member of the statins, inactivates GSK3B resulting in induction of Wnt signaling. This may be the neuroprotective effect of lovastatin. (cited information)
Formal Description
Interaction-ID: 44737

drug/chemical compound

Lovastatin

decreases_activity of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for Lovastatin or GSK3B
Comment Lovastatin could partially regulate beta-catenin expression by inhibiting the phosphorylated GSK3B activit.
Formal Description
Interaction-ID: 44743

drug/chemical compound

Lovastatin

affects_expression of

gene/protein

CTNNB1

by inhibiting the phosphorylated GSK3B activity
Drugbank entries Show/Hide entries for Lovastatin or CTNNB1
Comment Lovastatin activates the Wnt signaling to reduce the effect of Abeta (42.
Formal Description
Interaction-ID: 44751

drug/chemical compound

Lovastatin

increases_activity of

to reduce the effect of Abeta (42)
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Comment Statins like lovastatin inhibit 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA), blocking thereby cholesterol biosynthesis.(cited information)
Formal Description
Interaction-ID: 44775

drug/chemical compound

Lovastatin

decreases_activity of

gene/protein

HMGCR

blocking thereby cholesterol biosynthesis
Drugbank entries Show/Hide entries for Lovastatin or HMGCR
Comment Lovastatin could partially regulate beta-catenin expression by inhibiting the phosphorylated GSK3B activity.
Formal Description
Interaction-ID: 45039

drug/chemical compound

Lovastatin

increases_activity of

gene/protein

CTNNB1

by inhibiting the phosphorylated GSK3B activity
Drugbank entries Show/Hide entries for Lovastatin or CTNNB1