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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	4,308 (click here to show other Interactions for entry)
Diseases:	Metabolic
Organism:	Homo sapiens
Tissue/Cell line:	BTO:0000007 HEK-293 cell; BTO:0002181 HEK-293T cell
Publication type:	article
Reference:	Zhou F et al.(2011) Wnt/beta-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity Biochem. Biophys. Res. Commun. 412: 68-73 [PMID: 21798242]

Interaction Information:

Comment	Wnt/beta-catenin stabilizes endogenous AICD by increasing the protein half-life.
Formal Description Interaction-ID: 44132	process canonical Wnt signaling pathway increases_quantity of gene/protein APP (intracellular domain AICD) due to the increased protein stability by Wnt/beta-catenin

Comment	Wnt/beta-catenin signaling enhances the transcriptional activity of AICD.
Formal Description Interaction-ID: 44139	process canonical Wnt signaling pathway increases_activity of gene/protein APP (intracellular domain AICD) concerning the transcriptional activity of AICD

Comment	Wnt-1 is part of the Wnt receptor signaling pathway.
Formal Description Interaction-ID: 44600	gene/protein WNT1 increases_activity of process canonical Wnt signaling pathway

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