General Information:

Id: 4,300 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Homo sapiens
male
article
Reference: Tessari P et al.(1986) Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism J. Clin. Invest. 77: 1797-1804 [PMID: 3519679]

Interaction Information:

Comment To determine whether a resistance to insulin in type 1, insulin-dependent diabetes mellitus (IDDM) is extended to both glucose and amino acid metabolism, six normal male subjects and five male patients with IDDM, maintained in euglycemia with intravenous insulin administration, were infused with L-[4,5-3H]leucine (Leu) and [1-14C]alpha ketoisocaproate (KIC). In IDDM: (a) Peripheral hyperinsulinemia is required to normalize both fasting leucine metabolism and blood glucose concentrations. (b) At euglycemic hyperinsulinemic clamps, lower glucose disposal rates and a defective suppression of leucine-carbon appearance and oxidation were observed. We conclude that in type 1 diabetes a resistance to the metabolic effects of insulin on both glucose and amino acid metabolism is present.
Formal Description
Interaction-ID: 44095

complex/PPI

Insulin

increases_activity of