General Information:

Id: 43
Diseases: Diabetes mellitus, type I - [OMIM]
Mus musculus
ToI-beta (for Tet-On delta-I-kappa-B in beta cells)
BTO:0000991 pancreatic islet
article
Reference: Eldor R et al.(2006) Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents Proc. Natl. Acad. Sci. U.S.A. 103: 5072-5077 [PMID: 16551748]

Interaction Information:

Comment Upon exposure to cytokines (IL-1-beta and IFN-gamma), strong NF-kappa-B activation was observed in the islet cells nuclei.
Formal Description
Interaction-ID: 101

gene/protein

IL1B

increases_activity of

complex/PPI

NF-kappaB complex

Drugbank entries Show/Hide entries for IL1B
Comment The NF-kappa-B stimulation was significantly dampened in Dox-treated islets, and a reduction in the endogenous NF-kappa-B complex was also observed.
Formal Description
Interaction-ID: 102

drug/chemical compound

Doxycycline

decreases_activity of

complex/PPI

NF-kappaB complex

Drugbank entries Show/Hide entries for Doxycycline
Comment The NF-kappa-B activation mediates, in part, beta-cell death via induction of the expression of the inducible form of nitric oxide synthase and subsequent NO production.
Formal Description
Interaction-ID: 105

complex/PPI

NF-kappaB complex

increases_expression of

gene/protein

NOS2

and subsequent NO production
Drugbank entries Show/Hide entries for NOS2
Comment Dox-treated islets showed that NO formation was significantly inhibited as a result of NF-kappa-B blockade.
Formal Description
Interaction-ID: 108

drug/chemical compound

Doxycycline

decreases_expression of

gene/protein

NOS2

and subsequent NO production
Drugbank entries Show/Hide entries for Doxycycline or NOS2
Comment Dox-treated beta cells were significantly more resistant to cytokine-induced apoptosis than the control.
Formal Description
Interaction-ID: 109

drug/chemical compound

Doxycycline

decreases_activity of

Drugbank entries Show/Hide entries for Doxycycline
Comment Cytokine (Il-1-beta and IFN-gamma)-induced chemokine secretion is significantly reduced in islets from Dox-treated compared with that in untreated mice.
Formal Description
Interaction-ID: 110

gene/protein

IFNG

increases_expression of

gene/protein

CXCL9

secreted in the culture media of islets
Drugbank entries Show/Hide entries for IFNG
Comment Cytokine (Il-1-beta and IFN-gamma)-induced chemokine secretion is significantly reduced in islets from Dox-treated compared with that in untreated mice.
Formal Description
Interaction-ID: 111

gene/protein

IFNG

increases_expression of

gene/protein

CXCL10

secreted in the culture media of islets
Drugbank entries Show/Hide entries for IFNG or CXCL10
Comment Cytokine (Il-1-beta and IFN-gamma)-induced chemokine secretion is significantly reduced in islets from Dox-treated compared with that in untreated mice.
Formal Description
Interaction-ID: 112

drug/chemical compound

Doxycycline

decreases_expression of

gene/protein

CXCL10

secreted in the culture media of islets; in cytokine treated islets
Drugbank entries Show/Hide entries for Doxycycline or CXCL10
Comment Cytokine (Il-1-beta and IFN-gamma)-induced chemokine secretion is significantly reduced in islets from Dox-treated compared with that in untreated mice.
Formal Description
Interaction-ID: 113

drug/chemical compound

Doxycycline

increases_expression of

gene/protein

CXCL9

secreted in the culture media of islets; in cytokine treated islets
Drugbank entries Show/Hide entries for Doxycycline
Comment Cytokine (Il-1-beta and IFN-gamma) treatment induced apoptosis in pancreatic islets.
Formal Description
Interaction-ID: 117

gene/protein

IFNG

increases_activity of

Drugbank entries Show/Hide entries for IFNG