General Information:

Id: 429
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Rattus norvegicus
female
article
Reference: Lewin TM et al.(2001) Regulation of mitochondrial sn-glycerol-3-phosphate acyltransferase activity: response to feeding status is unique in various rat tissues and is discordant with protein expression Arch. Biochem. Biophys. 396: 119-127 [PMID: 11716470]

Interaction Information:

Comment Triacylglycerol plays a critical role in an organism's ability to withstand fuel deprivation, and dysregulation of triacylglycerol synthesis is important in the development of diseases such as obesity and diabetes.
Formal Description
Interaction-ID: 1872

drug/chemical compound

Triacylglycerol

affects_activity of

Comment Mitochondrial GPAT mRNA levels, protein expression, and activity are discordant. Liver, adipose tissue, and soleus muscle have high levels of GPAT mRNA but low protein expression, whereas heart and adrenal gland, tissues with low GPAT mRNA abundance, have the highest GPAT protein expression. In addition, heart, which has the highest expression of mitochondrial GPAT protein, has low mitochondrial GPAT specific activity. Liver and adipose tissue have the highest mitochondrial GPAT specific activity, but very low protein expression. These discrepancies between GPAT protein expression and activity suggest that mitochondrial GPAT may be regulated acutely by posttranslational modification.
Formal Description
Interaction-ID: 1873

affects_activity of

gene/protein

Mitochondrial GPAT

Comment GPAT protein expression and activity are regulated differently by fasting and refeeding in various rat tissues. In response to a 48-h fast, liver and adipose mitochondrial GPAT protein expression and activity decrease 30-50%. After 24-h refeeding of either chow or high-sucrose diet, mitochondrial GPAT protein expression and activity overshoot normal levels 30-60%. In kidney, mitochondrial GPAT protein and activity increase 65 and 30%, respectively, with refeeding, whereas in the heart, mitochondrial GPAT activity increases 2.3-fold after a fast, with no change in protein expression.
Formal Description
Interaction-ID: 1874

environment

fasting

decreases_expression of

gene/protein

Mitochondrial GPAT

in liver, in adipose tissue
Comment Mitochondrial GPAT activity in the neonatal rat constitutes a lower percentage of the total GPAT activity than in the adult.
Formal Description
Interaction-ID: 1875

process

aging

affects_activity of

gene/protein

Mitochondrial GPAT

Comment Triacylglycerol plays a critical role in an organism's ability to withstand fuel deprivation, and dysregulation of triacylglycerol synthesis is important in the development of diseases such as obesity and diabetes.
Formal Description
Interaction-ID: 12717

drug/chemical compound

Triacylglycerol

affects_activity of

disease

Obesity

Comment GPAT protein expression and activity are regulated differently by fasting and refeeding in various rat tissues. In response to a 48-h fast, liver and adipose mitochondrial GPAT protein expression and activity decrease 30-50%. After 24-h refeeding of either chow or high-sucrose diet, mitochondrial GPAT protein expression and activity overshoot normal levels 30-60%. In kidney, mitochondrial GPAT protein and activity increase 65 and 30%, respectively, with refeeding, whereas in the heart, mitochondrial GPAT activity increases 2.3-fold after a fast, with no change in protein expression.
Formal Description
Interaction-ID: 12718

environment

feeding after fasting

increases_expression of

gene/protein

Mitochondrial GPAT

in liver, in adipose tissue, in kidney
Comment GPAT protein expression and activity are regulated differently by fasting and refeeding in various rat tissues. In response to a 48-h fast, liver and adipose mitochondrial GPAT protein expression and activity decrease 30-50%. After 24-h refeeding of either chow or high-sucrose diet, mitochondrial GPAT protein expression and activity overshoot normal levels 30-60%. In kidney, mitochondrial GPAT protein and activity increase 65 and 30%, respectively, with refeeding, whereas in the heart, mitochondrial GPAT activity increases 2.3-fold after a fast, with no change in protein expression.
Formal Description
Interaction-ID: 12721

environment

feeding after fasting

NOT increases_expression of

gene/protein

Mitochondrial GPAT

in cardiac muscle
Comment GPAT protein expression and activity are regulated differently by fasting and refeeding in various rat tissues. In response to a 48-h fast, liver and adipose mitochondrial GPAT protein expression and activity decrease 30-50%. After 24-h refeeding of either chow or high-sucrose diet, mitochondrial GPAT protein expression and activity overshoot normal levels 30-60%. In kidney, mitochondrial GPAT protein and activity increase 65 and 30%, respectively, with refeeding, whereas in the heart, mitochondrial GPAT activity increases 2.3-fold after a fast, with no change in protein expression.
Formal Description
Interaction-ID: 12722

environment

feeding after fasting

increases_activity of

gene/protein

Mitochondrial GPAT

in cardiac muscle