General Information:

Id: 427
Diseases: Alzheimer disease - [OMIM]
Mus musculus
BTO:0000165 C2C12 cell
article
Reference: Lee HK et al.(2009) The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid Mol. Biol. Cell 20: 1533-1544 [PMID: 19144826]

Interaction Information:

Comment In cell culture, intraneuronal beta-amyloid expression inhibited both insulin-induced Akt phosphorylation and activity.
Formal Description
Interaction-ID: 1867

gene/protein

Amyloid beta peptide

decreases_phosphorylation of

gene/protein

AKT1

if AKT is insulin-induced;
Drugbank entries Show/Hide entries for AKT1
Comment In cell culture, intraneuronal beta-amyloid expression inhibited both insulin-induced Akt phosphorylation and activity.
Formal Description
Interaction-ID: 1868

gene/protein

Amyloid beta peptide

decreases_activity of

gene/protein

AKT1

if AKT is insulin-induced;
Drugbank entries Show/Hide entries for AKT1
Comment Intraneuronal beta-amyloid blocked the association between PDK and Akt in cell-based and in vitro experiments.
Formal Description
Interaction-ID: 1869

gene/protein

Amyloid beta peptide

decreases_activity of

complex/PPI

AKT1-PDPK1 complex

Comment Beta-amyloid did not interrupt Akt or PI3K activities (once stimulated) nor did it affect more proximal signal events.
Formal Description
Interaction-ID: 1879

gene/protein

Amyloid beta peptide

NOT decreases_activity of

Comment Intraneuronal beta-amyloid blocked the association between PDK and Akt in cell-based and in vitro experiments.
Formal Description
Interaction-ID: 1883

gene/protein

AKT1

interacts (colocalizes) with

gene/protein

PDPK1

Drugbank entries Show/Hide entries for AKT1 or PDPK1
Comment Intraneuronal beta-amyloid blocked the association between PDK and Akt in cell-based and in vitro experiments. The interaction of PDK with Akt1 is interrupted by intracellular beta-amyloid42.
Formal Description
Interaction-ID: 1884

gene/protein

AKT1

NOT interacts (colocalizes) with

gene/protein

PDPK1

in presence of intraneuronal beta-amyloid and in presence of intracellular beta-amyloid(42);
Drugbank entries Show/Hide entries for AKT1 or PDPK1
Comment Intracellular beta-amyloid expression decreases myotube length and caliber and increases pyknotic nuclei.
Formal Description
Interaction-ID: 1993

gene/protein

Amyloid beta peptide

decreases_activity of

Comment Intracellular beta-amyloid expression decreases myotube length and caliber and increases pyknotic nuclei.
Formal Description
Interaction-ID: 1994

gene/protein

Amyloid beta peptide

decreases_activity of

by increasing the pyknotic nuclei
Comment Immunoblot of p-GSK-3alpha/beta shows significantly inhibited phosphorylation in cultures treated with insulin.
Formal Description
Interaction-ID: 1997

complex/PPI

Insulin

decreases_phosphorylation of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for GSK3B
Comment The stimulated activity of Akt1 on the GSK substrate is markedly inhibited in the presence of intracellular beta-amyloid42.
Formal Description
Interaction-ID: 2001

decreases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment The stimulated activity of Akt1 on the GSK substrate is markedly inhibited in the presence of intracellular beta-amyloid42.
Formal Description
Interaction-ID: 2004

decreases_phosphorylation of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment The interaction of PDK with Akt1 is interrupted by intracellular beta-amyloid42.
Formal Description
Interaction-ID: 2006

decreases_activity of

complex/PPI

AKT1-PDPK1 complex