General Information:

Id: 4,266 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
review
Reference: Lauterbach EC(2012) Psychotropic drug effects on gene transcriptomics relevant to Alzheimer disease Alzheimer Dis Assoc Disord 26: 1-7 [PMID: 21399480]

Interaction Information:

Comment Influence of psychotropic drugs on AD-relevant genes: Lithium (down-regulate TNF) and fluoxetine reduce AD risk.
Formal Description
Interaction-ID: 43588

drug/chemical compound

Lithium

decreases_activity of

by down-regulation of TNF
Drugbank entries Show/Hide entries for Lithium
Comment Influence of psychotropic drugs on AD-relevant genes: Lithium down-regulates TNF and reduces AD risk.
Formal Description
Interaction-ID: 43593

drug/chemical compound

Lithium

decreases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for Lithium or TNF
Comment Influence of psychotropic drugs on AD-relevant genes: Lithium coadministered with antipsychotics down-regulates IL1B and reduces AD risk.
Formal Description
Interaction-ID: 43631

drug/chemical compound

Lithium

decreases_expression of

gene/protein

IL1B

if coadministered with antipsychotics
Drugbank entries Show/Hide entries for Lithium or IL1B