General Information:

Id: 4,266
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
review
Reference: Lauterbach EC(2012) Psychotropic drug effects on gene transcriptomics relevant to Alzheimer disease Alzheimer Dis Assoc Disord 26: 1-7 [PMID: 21399480]

Interaction Information:

Comment Influence of psychotropic drugs on AD-relevant genes: Lithium (down-regulate TNF) and fluoxetine reduce AD risk.
Formal Description
Interaction-ID: 43588

drug/chemical compound

Lithium

decreases_activity of

by down-regulation of TNF
Drugbank entries Show/Hide entries for Lithium
Comment Influence of psychotropic drugs on AD-relevant genes: Lithium and fluoxetine (up-regulates CLU, SORCS1, NEDD9, GRN, and ECE1) reduce AD risk.
Formal Description
Interaction-ID: 43592

drug/chemical compound

Fluoxetine

decreases_activity of

by up-regulation of CLU, SORCS1, NEDD9, GRN, and ECE1
Drugbank entries Show/Hide entries for Fluoxetine
Comment Influence of psychotropic drugs on AD-relevant genes: Lithium down-regulates TNF and reduces AD risk.
Formal Description
Interaction-ID: 43593

drug/chemical compound

Lithium

decreases_expression of

gene/protein

TNF

Drugbank entries Show/Hide entries for Lithium or TNF
Comment Influence of psychotropic drugs on AD-relevant genes: Fluoxetine up-regulates CLU, SORCS1, NEDD9, GRN, and ECE1, and reduces AD risk.
Formal Description
Interaction-ID: 43597

drug/chemical compound

Fluoxetine

increases_expression of

gene/protein

SORCS1

Drugbank entries Show/Hide entries for Fluoxetine
Comment Influence of psychotropic drugs on AD-relevant genes: Fluoxetine up-regulates CLU, SORCS1, NEDD9, GRN, and ECE1, and reduces AD risk.
Formal Description
Interaction-ID: 43599

drug/chemical compound

Fluoxetine

increases_expression of

gene/protein

CLU

Drugbank entries Show/Hide entries for Fluoxetine
Comment Influence of psychotropic drugs on AD-relevant genes: Fluoxetine up-regulates CLU, SORCS1, NEDD9, GRN, and ECE1, and reduces AD risk.
Formal Description
Interaction-ID: 43600

drug/chemical compound

Fluoxetine

increases_expression of

gene/protein

NEDD9

Drugbank entries Show/Hide entries for Fluoxetine
Comment Influence of psychotropic drugs on AD-relevant genes: Fluoxetine up-regulates CLU, SORCS1, NEDD9, GRN, and ECE1, and reduces AD risk.
Formal Description
Interaction-ID: 43601

drug/chemical compound

Fluoxetine

increases_expression of

gene/protein

GRN

Drugbank entries Show/Hide entries for Fluoxetine
Comment Influence of psychotropic drugs on AD-relevant genes: Fluoxetine up-regulates CLU, SORCS1, NEDD9, GRN, and ECE1, and reduces AD risk.
Formal Description
Interaction-ID: 43602

drug/chemical compound

Fluoxetine

increases_expression of

gene/protein

ECE1

Drugbank entries Show/Hide entries for Fluoxetine or ECE1
Comment Influence of psychotropic drugs on AD-relevant genes: atypical antipsychotics down-regulate TF and decrease the AD risk.
Formal Description
Interaction-ID: 43624

drug/chemical compound

Atypical antipsychotic drug

decreases_expression of

gene/protein

TF

Comment Influence of psychotropic drugs on AD-relevant genes: atypical antipsychotics down-regulate TF and decrease the AD risk.
Formal Description
Interaction-ID: 43625

drug/chemical compound

Atypical antipsychotic drug

decreases_activity of

by down-regulation of TF
Comment Influence of psychotropic drugs on AD-relevant genes: risperidone down-regulates IL1B and decreases the AD risk.
Formal Description
Interaction-ID: 43626

drug/chemical compound

Risperidone

decreases_activity of

by down-regulation of IL1B
Drugbank entries Show/Hide entries for Risperidone
Comment Influence of psychotropic drugs on AD-relevant genes: risperidone down-regulates IL1B and decreases the AD risk.
Formal Description
Interaction-ID: 43627

drug/chemical compound

Risperidone

decreases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for Risperidone or IL1B
Comment Influence of psychotropic drugs on AD-relevant genes: olanzapine up-regulates TFAM, down-regulates PRNP, and decreases the AD risk.
Formal Description
Interaction-ID: 43628

drug/chemical compound

Olanzapine

decreases_activity of

by up-regulation of TFAM, and down-regulation of PRNP
Drugbank entries Show/Hide entries for Olanzapine
Comment Influence of psychotropic drugs on AD-relevant genes: olanzapine up-regulates TFAM, down-regulates PRNP, and decreases the AD risk.
Formal Description
Interaction-ID: 43629

drug/chemical compound

Olanzapine

increases_expression of

gene/protein

TFAM

Drugbank entries Show/Hide entries for Olanzapine
Comment Influence of psychotropic drugs on AD-relevant genes: olanzapine up-regulates TFAM, down-regulates PRNP, and decreases the AD risk.
Formal Description
Interaction-ID: 43630

drug/chemical compound

Olanzapine

decreases_expression of

gene/protein

PRNP

Drugbank entries Show/Hide entries for Olanzapine or PRNP
Comment Influence of psychotropic drugs on AD-relevant genes: Lithium coadministered with antipsychotics down-regulates IL1B and reduces AD risk.
Formal Description
Interaction-ID: 43631

drug/chemical compound

Lithium

decreases_expression of

gene/protein

IL1B

if coadministered with antipsychotics
Drugbank entries Show/Hide entries for Lithium or IL1B
Comment Enhanced AD risk by neuroleptics (up-regulate TF).
Formal Description
Interaction-ID: 43632

drug/chemical compound

Neuroleptic drug

increases_activity of

by up-regulation of TF
Comment Enhanced AD risk by neuroleptics (up-regulate TF).
Formal Description
Interaction-ID: 43633

drug/chemical compound

Neuroleptic drug

increases_expression of

gene/protein

TF

Comment Psychotropic drugs influence gene transcriptomics relevant to Alzheimer disease.
Formal Description
Interaction-ID: 43634

affects_activity of

Comment Enhanced AD risk by haloperidol (up-regulates IL1B and PION).
Formal Description
Interaction-ID: 43635

drug/chemical compound

Haloperidol

increases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for Haloperidol or IL1B
Comment Enhanced AD risk by haloperidol (up-regulates IL1B and PION).
Formal Description
Interaction-ID: 43636

drug/chemical compound

Haloperidol

increases_expression of

gene/protein

GSAP

Drugbank entries Show/Hide entries for Haloperidol
Comment Enhanced AD risk by haloperidol (up-regulates IL1B and PION).
Formal Description
Interaction-ID: 43637

drug/chemical compound

Haloperidol

increases_activity of

by up-regulation of IL1B and PION
Drugbank entries Show/Hide entries for Haloperidol
Comment Enhanced AD risk by olanzapine (down-regulates THRA and PRNP, up-regulates IL1A).
Formal Description
Interaction-ID: 43638

drug/chemical compound

Olanzapine

decreases_expression of

gene/protein

THRA

Drugbank entries Show/Hide entries for Olanzapine or THRA
Comment Enhanced AD risk by olanzapine (down-regulates THRA and PRNP, up-regulates IL1A).
Formal Description
Interaction-ID: 43639

drug/chemical compound

Olanzapine

decreases_expression of

gene/protein

PRNP

Drugbank entries Show/Hide entries for Olanzapine or PRNP
Comment Enhanced AD risk by olanzapine (down-regulates THRA and PRNP, up-regulates IL1A).
Formal Description
Interaction-ID: 43640

drug/chemical compound

Olanzapine

increases_expression of

gene/protein

IL1A

Drugbank entries Show/Hide entries for Olanzapine
Comment Enhanced AD risk by olanzapine (down-regulates THRA and PRNP, up-regulates IL1A).
Formal Description
Interaction-ID: 43641

drug/chemical compound

Olanzapine

increases_activity of

by down-regulation of THRA and PRNP, and up-regulation of IL1A
Drugbank entries Show/Hide entries for Olanzapine
Comment Enhanced AD risk by chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).
Formal Description
Interaction-ID: 43642

drug/chemical compound

Chlorpromazine

increases_activity of

by up-regulation of IL1B
Drugbank entries Show/Hide entries for Chlorpromazine
Comment Enhanced AD risk by chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).
Formal Description
Interaction-ID: 43643

drug/chemical compound

Chlorpromazine

increases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for Chlorpromazine or IL1B
Comment Enhanced AD risk by chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).
Formal Description
Interaction-ID: 43644

drug/chemical compound

Imipramine

increases_activity of

by up-regulation of IL1B
Drugbank entries Show/Hide entries for Imipramine
Comment Enhanced AD risk by chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).
Formal Description
Interaction-ID: 43645

drug/chemical compound

Imipramine

increases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for Imipramine or IL1B
Comment Enhanced AD risk by chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).
Formal Description
Interaction-ID: 43646

drug/chemical compound

Maprotiline

increases_activity of

by up-regulation of IL1B
Drugbank entries Show/Hide entries for Maprotiline
Comment Enhanced AD risk by chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).
Formal Description
Interaction-ID: 43647

drug/chemical compound

Maprotiline

increases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for Maprotiline or IL1B
Comment Enhanced AD risk by chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).
Formal Description
Interaction-ID: 43648

drug/chemical compound

Fluvoxamine

increases_activity of

by up-regulation of IL1B
Drugbank entries Show/Hide entries for Fluvoxamine
Comment Enhanced AD risk by chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).
Formal Description
Interaction-ID: 43649

drug/chemical compound

Diazepam

increases_expression of

gene/protein

IL1B

Drugbank entries Show/Hide entries for Diazepam or IL1B
Comment Enhanced AD risk by chlorpromazine, imipramine, maprotiline, fluvoxamine, and diazepam (up-regulate IL1B).
Formal Description
Interaction-ID: 43650

drug/chemical compound

Diazepam

increases_activity of

by up-regulation of IL1B
Drugbank entries Show/Hide entries for Diazepam