General Information:

Id: 423 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Harraz MM et al.(2008) SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model J. Clin. Invest. 118: 659-670 [PMID: 18219391]

Interaction Information:

Comment Overexpression only of the mutant SOD1 proteins enhanced NADPH-dependent superoxide production in endomembranes from both glial and neuronal cell types and significantly increased cell death.
Formal Description
Interaction-ID: 1846

gene/protein mutant

SOD1-p.G93A

increases_quantity of

drug/chemical compound

O2-

if SOD1G93A is overexpressed