General Information:

Id: 4,231 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Schizophrenia - [OMIM]
Homo sapiens
Reference: Arranz B et al.(2004) Insulin resistance and increased leptin concentrations in noncompliant schizophrenia patients but not in antipsychotic-naive first-episode schizophrenia patients J Clin Psychiatry 65: 1335-1342 [PMID: 15491236]

Interaction Information:

Comment The antipsychotic-free group consisted of patients with a confirmed diagnosis of paranoid schizophrenia, who had been taking several antipsychotic drugs for about 10 years during different time lengths, combining periods of active treatment with those without compliance. These patients had been off psychotropic (antipsychotic, antidepressant, or mood stabilizer) treatment for about 17 months because of noncompliance. The antipsychotic-free patients showed significantly increased insulin and C-peptide concentrations and a significantly higher degree of insulin resistance, as measured with the HOMA index, in comparison with the antipsychotic-naive patients and the control group. Significantly increased leptin concentrations were also noted in the antipsychotic-free patients and were attributed to the effects of body mass index. The results reported in this study suggest the effect of previous antipsychotic treatment on glucose metabolism parameters and weight-related hormones such as leptin, while ruling out a preexisting impairment of glucose metabolism in never-medicated first-episode schizophrenic patients.
Formal Description
Interaction-ID: 43238

affects_activity of