General Information:
Id: | 422 (click here to show other Interactions for entry) |
Diseases: |
Amyotrophic lateral sclerosis
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Homo sapiens | |
MO59J glioblastoma cell line, transfected with WT, L8Q and G93A forms of human SOD1 | |
article | |
Reference: | Harraz MM et al.(2008) SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model J. Clin. Invest. 118: 659-670 [PMID: 18219391] |
Interaction Information:
Comment | Overexpression only of the mutant SOD1 proteins enhanced NADPH-dependent superoxide production in endomembranes from both glial and neuronal cell types and significantly increased cell death. |
Formal Description Interaction-ID: 1836 |
gene/protein mutant increases_quantity of drug/chemical compound |
Comment | Both SOD1G93A and SOD1L8Q mutant proteins elevated Rac1-GTP levels in MO59J cells compared with overexpression of SOD1WT. |
Formal Description Interaction-ID: 1842 |
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