General Information:

Id: 4,225 (click here to show other Interactions for entry)
Diseases: Circadian rhythm
Rattus norvegicus
article
Reference: Bhattacharya A et al.(2013) Potentiation of inhibitory synaptic transmission by extracellular ATP in rat suprachiasmatic nuclei J. Neurosci. 33: 8035-8044 [PMID: 23637193]

Interaction Information:

Comment The hypothalamic suprachiasmatic nuclei (SCN), the circadian master clock in mammals, releases ATP in a rhythm. The expression and function of ATP-gated P2X receptors (P2XRs) were investigated in the SCN neurons of slices isolated from the brain of 16- to 20-day-old rats. Quantitative RT-PCR showed that the SCN contains mRNA for P2X 1-7 receptors and several G-protein-coupled P2Y receptors. Among the P2XR subunits, the P2X2, P2X7, P2X4 mRNAs were the most abundant.
Formal Description
Interaction-ID: 43207

process

circadian rhythm

is localized in

tissue/cell line

suprachiasmatic nucleus

Comment The hypothalamic suprachiasmatic nuclei (SCN), the circadian master clock in mammals, releases ATP in a rhythm. The expression and function of ATP-gated P2X receptors (P2XRs) were investigated in the SCN neurons of slices isolated from the brain of 16- to 20-day-old rats. Quantitative RT-PCR showed that the SCN contains mRNA for P2X 1-7 receptors and several G-protein-coupled P2Y receptors. Among the P2XR subunits, the P2X2, P2X7, P2X4 mRNAs were the most abundant.
Formal Description
Interaction-ID: 43208

process

circadian rhythm

affects_activity of

process

ATP release