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Comment
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The hypothalamic suprachiasmatic nuclei (SCN), the circadian master clock in mammals, releases ATP in a rhythm. The expression and function of ATP-gated P2X receptors (P2XRs) were investigated in the SCN neurons of slices isolated from the brain of 16- to 20-day-old rats. Quantitative RT-PCR showed that the SCN contains mRNA for P2X 1-7 receptors and several G-protein-coupled P2Y receptors. Among the P2XR subunits, the P2X2, P2X7, P2X4 mRNAs were the most abundant.
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Formal Description Interaction-ID: 43207
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Comment
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The hypothalamic suprachiasmatic nuclei (SCN), the circadian master clock in mammals, releases ATP in a rhythm. The expression and function of ATP-gated P2X receptors (P2XRs) were investigated in the SCN neurons of slices isolated from the brain of 16- to 20-day-old rats. Quantitative RT-PCR showed that the SCN contains mRNA for P2X 1-7 receptors and several G-protein-coupled P2Y receptors. Among the P2XR subunits, the P2X2, P2X7, P2X4 mRNAs were the most abundant.
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Formal Description Interaction-ID: 43208
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