General Information:

Id: 4,218 (click here to show other Interactions for entry)
Diseases: Circadian rhythm
Sleep disorders
Mus musculus
article
Reference: Deboer T et al.(2013) Reduced sleep and low adenosinergic sensitivity in cacna1a R192Q mutant mice Sleep 36: 127-136 [PMID: 23288979]

Interaction Information:

Comment Cacna1a R192Q mice, which have a gain-of-function mutation in CaV2.1 Ca2+ channels, sleep less than wild-type mice, show reduced responsiveness to caffeine and CPA, and appear to live under a higher sleep pressure, suggesting that Cacna1a R192Q mice are less susceptible to stimulation via adenosinergic receptors.
Formal Description
Interaction-ID: 43188

drug/chemical compound

Caffeine

increases_activity of

complex/PPI

Voltage-gated calcium channel

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