General Information:

Id: 4,213
Diseases: Circadian rhythm
Sleep disorders
Homo sapiens
article
Reference: Moller-Levet CS et al.(2013) Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome Proc. Natl. Acad. Sci. U.S.A. 110 [PMID: 23440187]

Interaction Information:

Comment Twenty-six participants were exposed to 1 wk of insufficient sleep (sleep-restriction condition 5.70 h, SEM = 0.03 sleep per 24 h) and 1 wk of sufficient sleep (control condition 8.50 h sleep, SEM = 0.11). Genes with maximum transcript levels during the biological day included lipid metabolism transcripts (ABCA1, ABCD1, ABCG1).
Formal Description
Interaction-ID: 43172

environment

daytime

increases_expression of

gene/protein

ABCG1

under sleep-restriction condition
Drugbank entries Show/Hide entries for ABCG1
Comment Twenty-six participants were exposed to 1 wk of insufficient sleep (sleep-restriction condition 5.70 h, SEM = 0.03 sleep per 24 h) and 1 wk of sufficient sleep (control condition 8.50 h sleep, SEM = 0.11). Genes with maximum transcript levels during the biological day included lipid metabolism transcripts (ABCA1, ABCD1, ABCG1).
Formal Description
Interaction-ID: 43173

environment

sleep restriction

increases_expression of

gene/protein

ABCG1

Drugbank entries Show/Hide entries for ABCG1
Comment Twenty-six participants were exposed to 1 wk of insufficient sleep (sleep-restriction condition 5.70 h, SEM = 0.03 sleep per 24 h) and 1 wk of sufficient sleep (control condition 8.50 h sleep, SEM = 0.11). Genes with maximum transcript levels during the biological day included lipid metabolism transcripts (ABCA1, ABCD1, ABCG1).
Formal Description
Interaction-ID: 43174

gene/protein

ABCG1

increases_activity of

Drugbank entries Show/Hide entries for ABCG1
Comment The two genes that were most significantly affected by sleep condition were MFNG and DCAF5, which were down-regulated in response to insufficient sleep but had not previously been directly implicated in sleep regulation or circadian rhythms.
Formal Description
Interaction-ID: 47010

environment

sleep restriction

decreases_expression of

gene/protein

MFNG

Comment The two genes that were most significantly affected by sleep condition were MFNG and DCAF5, which were down-regulated in response to insufficient sleep but had not previously been directly implicated in sleep regulation or circadian rhythms.
Formal Description
Interaction-ID: 47011

environment

sleep restriction

decreases_expression of

gene/protein

DCAF5

Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47012

environment

sleep restriction

decreases_expression of

gene/protein

RORA

Drugbank entries Show/Hide entries for RORA
Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47013

environment

sleep restriction

decreases_expression of

gene/protein

IL6

Drugbank entries Show/Hide entries for IL6
Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47014

environment

sleep restriction

decreases_expression of

gene/protein

PER2

Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47015

environment

sleep restriction

decreases_expression of

gene/protein

PER3

Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47016

environment

sleep restriction

decreases_expression of

gene/protein

TIMELESS

Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47017

environment

sleep restriction

decreases_expression of

gene/protein

CAMK2D

Drugbank entries Show/Hide entries for CAMK2D
Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47018

environment

sleep restriction

increases_expression of

gene/protein

PRDX5

Drugbank entries Show/Hide entries for PRDX5
Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47019

environment

sleep restriction

increases_expression of

gene/protein

PRDX2

Drugbank entries Show/Hide entries for PRDX2
Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47020

environment

sleep restriction

increases_expression of

gene/protein

DEC1

Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47021

environment

sleep restriction

increases_expression of

gene/protein

CSNK1E

Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47022

environment

sleep restriction

increases_expression of

gene/protein

RHO

Drugbank entries Show/Hide entries for RHO
Comment Genes related to circadian rhythms and sleep, which were down-regulated after sleep restriction, included RORA, IL6, PER2, PER3, TIMELESS, and CAMK2D; PRDX5, PRDX2, DEC1, CSNK1E, RHO, and OPN1LW were up-regulated.
Formal Description
Interaction-ID: 47023

environment

sleep restriction

increases_expression of

gene/protein

OPN1LW

Comment Prevalent circadian genes were defined as those targeted by probes that showed a significant circadian oscillation in transcript levels. Assessment of individual expression profiles for a prevalent oscillatory component with a 24-h period in the control condition identified 1,855 circadian genes, which included PER1, PER2, PER3, NPAS2, CSNK1E, RORA, NR1D1 (REVERB-alpha), NR1D2 (REV-ERB-beta), and other genes associated with circadian rhythms, sleep, and metabolism.
Formal Description
Interaction-ID: 47025

affects_expression of

gene/protein

PER1

Comment Prevalent circadian genes were defined as those targeted by probes that showed a significant circadian oscillation in transcript levels. Assessment of individual expression profiles for a prevalent oscillatory component with a 24-h period in the control condition identified 1,855 circadian genes, which included PER1, PER2, PER3, NPAS2, CSNK1E, RORA, NR1D1 (REVERB-alpha), NR1D2 (REV-ERB-beta), and other genes associated with circadian rhythms, sleep, and metabolism.
Formal Description
Interaction-ID: 47026

affects_expression of

gene/protein

PER2

Comment Prevalent circadian genes were defined as those targeted by probes that showed a significant circadian oscillation in transcript levels. Assessment of individual expression profiles for a prevalent oscillatory component with a 24-h period in the control condition identified 1,855 circadian genes, which included PER1, PER2, PER3, NPAS2, CSNK1E, RORA, NR1D1 (REVERB-alpha), NR1D2 (REV-ERB-beta), and other genes associated with circadian rhythms, sleep, and metabolism.
Formal Description
Interaction-ID: 47027

affects_expression of

gene/protein

PER3

Comment Prevalent circadian genes were defined as those targeted by probes that showed a significant circadian oscillation in transcript levels. Assessment of individual expression profiles for a prevalent oscillatory component with a 24-h period in the control condition identified 1,855 circadian genes, which included PER1, PER2, PER3, NPAS2, CSNK1E, RORA, NR1D1 (REVERB-alpha), NR1D2 (REV-ERB-beta), and other genes associated with circadian rhythms, sleep, and metabolism.
Formal Description
Interaction-ID: 47028

affects_expression of

gene/protein

NPAS2

Comment Prevalent circadian genes were defined as those targeted by probes that showed a significant circadian oscillation in transcript levels. Assessment of individual expression profiles for a prevalent oscillatory component with a 24-h period in the control condition identified 1,855 circadian genes, which included PER1, PER2, PER3, NPAS2, CSNK1E, RORA, NR1D1 (REVERB-alpha), NR1D2 (REV-ERB-beta), and other genes associated with circadian rhythms, sleep, and metabolism.
Formal Description
Interaction-ID: 47029

affects_expression of

gene/protein

CSNK1E

Comment Prevalent circadian genes were defined as those targeted by probes that showed a significant circadian oscillation in transcript levels. Assessment of individual expression profiles for a prevalent oscillatory component with a 24-h period in the control condition identified 1,855 circadian genes, which included PER1, PER2, PER3, NPAS2, CSNK1E, RORA, NR1D1 (REVERB-alpha), NR1D2 (REV-ERB-beta), and other genes associated with circadian rhythms, sleep, and metabolism.
Formal Description
Interaction-ID: 47030

affects_expression of

gene/protein

RORA

Drugbank entries Show/Hide entries for RORA
Comment Prevalent circadian genes were defined as those targeted by probes that showed a significant circadian oscillation in transcript levels. Assessment of individual expression profiles for a prevalent oscillatory component with a 24-h period in the control condition identified 1,855 circadian genes, which included PER1, PER2, PER3, NPAS2, CSNK1E, RORA, NR1D1 (REVERB-alpha), NR1D2 (REV-ERB-beta), and other genes associated with circadian rhythms, sleep, and metabolism.
Formal Description
Interaction-ID: 47031

affects_expression of

gene/protein

NR1D1

Comment Prevalent circadian genes were defined as those targeted by probes that showed a significant circadian oscillation in transcript levels. Assessment of individual expression profiles for a prevalent oscillatory component with a 24-h period in the control condition identified 1,855 circadian genes, which included PER1, PER2, PER3, NPAS2, CSNK1E, RORA, NR1D1 (REVERB-alpha), NR1D2 (REV-ERB-beta), and other genes associated with circadian rhythms, sleep, and metabolism.
Formal Description
Interaction-ID: 47032

affects_expression of

gene/protein

NR1D2

Comment The expression of SLC2A5 was up-regulated after sleep restriction in human blood samples.
Formal Description
Interaction-ID: 51861

phenotype

sleep duration

affects_expression of

gene/protein

SLC2A5