General Information:

Id: 420
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0001279 spinal cord; BTO:0000142 brain; BTO:0000759 liver
article
Reference: Harraz MM et al.(2008) SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model J. Clin. Invest. 118: 659-670 [PMID: 18219391]

Interaction Information:

Comment Analysis of transgenic mice overexpressing SOD1WT or SOD1G93A demonstrated that only the mutant form of SOD1 enhanced NADPH-dependent superoxide production in brain, spinal cord and liver.
Formal Description
Interaction-ID: 1833

gene/protein mutant

SOD1-p.G93A

increases_quantity of

drug/chemical compound

O2-

in brain, spinal cord and liver; if SOD1G93A is overexpressed