General Information:

Id: 4,198 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Canto C et al.(2006) Neuregulins mediate calcium-induced glucose transport during muscle contraction J. Biol. Chem. 281 [PMID: 16740635]

Interaction Information:

Comment Caffeine-induced increases in cytosolic Ca2+ mediate a metalloproteinase-dependent release of neuregulins, which stimulates tyrosine phosphorylation of ErbB4 receptors. Activation of ErbB4 is necessary for Ca2+-derived effects on glucose transport.
Formal Description
Interaction-ID: 43089

drug/chemical compound


increases_activity of

into cytosol, in skeletal muscle
Drugbank entries Show/Hide entries for Caffeine