General Information:

Id: 4,198
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
male
article
Reference: Canto C et al.(2006) Neuregulins mediate calcium-induced glucose transport during muscle contraction J. Biol. Chem. 281 [PMID: 16740635]

Interaction Information:

Comment The effects of ex vivo electrically stimulated muscle contraction on tyrosine phosphorylation of neuregulin receptors were examined. Contraction stimulated phosphorylation of ErbB4 and ErbB2 but not ErbB3 receptors.
Formal Description
Interaction-ID: 43082

increases_phosphorylation of

gene/protein

ERBB4

in skeletal muscle
Comment The effects of ex vivo electrically stimulated muscle contraction on tyrosine phosphorylation of neuregulin receptors were examined. Contraction stimulated phosphorylation of ErbB4 and ErbB2 but not ErbB3 receptors.
Formal Description
Interaction-ID: 43085

increases_phosphorylation of

gene/protein

ERBB2

in skeletal muscle
Drugbank entries Show/Hide entries for ERBB2
Comment The effects of ex vivo electrically stimulated muscle contraction on tyrosine phosphorylation of neuregulin receptors were examined. Contraction stimulated phosphorylation of ErbB4 and ErbB2 but not ErbB3 receptors.
Formal Description
Interaction-ID: 43086

NOT increases_phosphorylation of

gene/protein

ERBB3

in skeletal muscle
Comment Caffeine-induced increases in cytosolic Ca2+ mediate a metalloproteinase-dependent release of neuregulins, which stimulates tyrosine phosphorylation of ErbB4 receptors. Activation of ErbB4 is necessary for Ca2+-derived effects on glucose transport.
Formal Description
Interaction-ID: 43089

drug/chemical compound

Caffeine

increases_activity of

into cytosol, in skeletal muscle
Drugbank entries Show/Hide entries for Caffeine
Comment Caffeine-induced increases in cytosolic Ca2+ mediate a metalloproteinase-dependent release of neuregulins, which stimulates tyrosine phosphorylation of ErbB4 receptors. Activation of ErbB4 is necessary for Ca2+-derived effects on glucose transport.
Formal Description
Interaction-ID: 43095

increases_activity of

gene/protein

Membrane metalloproteinase

in skeletal muscle
Comment Caffeine-induced increases in cytosolic Ca2+ mediate a metalloproteinase-dependent release of neuregulins, which stimulates tyrosine phosphorylation of ErbB4 receptors. Activation of ErbB4 is necessary for Ca2+-derived effects on glucose transport.
Formal Description
Interaction-ID: 43097

gene/protein

Membrane metalloproteinase

increases_quantity of

gene/protein

NRG

in skeletal muscle
Comment Caffeine-induced increases in cytosolic Ca2+ mediate a metalloproteinase-dependent release of neuregulins, which stimulates tyrosine phosphorylation of ErbB4 receptors. Activation of ErbB4 is necessary for Ca2+-derived effects on glucose transport.
Formal Description
Interaction-ID: 43099

gene/protein

NRG

increases_phosphorylation of

gene/protein

ERBB4

in skeletal muscle; at Tyr residues
Comment Caffeine-induced increases in cytosolic Ca2+ mediate a metalloproteinase-dependent release of neuregulins, which stimulates tyrosine phosphorylation of ErbB4 receptors. Activation of ErbB4 is necessary for Ca2+-derived effects on glucose transport.
Formal Description
Interaction-ID: 43100

gene/protein

ERBB4

increases_activity of

process

glucose import

in skeletal muscle