General Information:

Id: 418 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
brain
article
Reference: Lee HK et al.(2009) The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol. Biol. Cell 20: 1533-1544 [PMID: 19144826]

Interaction Information:

Comment Intraneuronal beta-amyloid accumulates early in Alzheimer disease and inclusion body myositis.
Formal Description
Interaction-ID: 1876

increases_quantity of

gene/protein

Amyloid beta peptide

Comment One possibility for the down-regulation of Akt activation in AD brain is direct inhibition mediated by an increase in cellular beta-amyloid.
Formal Description
Interaction-ID: 1954

gene/protein

Amyloid beta peptide

decreases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment The association of beta-amyloid with each of Akt1 and PDK was increased in AD brain. Beta-amyloid has specific affinity for PDK/Akt.
Formal Description
Interaction-ID: 1955

gene/protein

Amyloid beta peptide

interacts (colocalizes) with

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment The association of beta-amyloid with each of Akt1 and PDK was increased in AD brain.
Formal Description
Interaction-ID: 14040

gene/protein

Amyloid beta peptide

interacts (colocalizes) with

gene/protein

PDPK1

Drugbank entries Show/Hide entries for PDPK1
Comment Intraneuronal beta-amyloid accumulates early in Alzheimer disease and inclusion body myositis.
Formal Description
Interaction-ID: 14041

phenotype

inclusion body myositis

increases_quantity of

gene/protein

Amyloid beta peptide