General Information:

Id: 4,158 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Ruiz de Azua I et al.(2010) RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo Proc. Natl. Acad. Sci. U.S.A. 107: 7999-8004 [PMID: 20385802]

Interaction Information:

Comment RGS4 knockdown enhances M3 muscarinic receptor-mediated calcium import and insulin release in MIN6 cells. Similar findings were obtained using pancreatic islets prepared from RGS4-deficient mice.
Formal Description
Interaction-ID: 42872

gene/protein

RGS4

affects_activity of

process

insulin secretion involved in cellular response to glucose stimulus

via CHRM3