General Information:

Id: 4,140 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Cheng K et al.(2010) Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets J. Clin. Invest. 120: 2171-2183 [PMID: 20440072]

Interaction Information:

Comment The effect of adding iron in the form of ferric citrate was studied. At high doses, there was obvious cell death. At lower doses, there were significant decreases in Hif1a, Hnf4a, Glut1, and Glut2 expression. There was also significantly impaired glucose-stimulated insulin secretion (GSIS), with only a nonsignificant 13% increase, following high glucose in iron-treated cells.
Formal Description
Interaction-ID: 42728

drug/chemical compound


decreases_activity of

in pancreas, in pancreatic beta cells
Comment Increasing HIF-1alpha levels by inhibiting its degradation through iron chelation markedly improved insulin secretion and glucose tolerance in control mice fed a high-fat diet but not in beta-Hif1a-null mice.
Formal Description
Interaction-ID: 42729

drug/chemical compound

Iron chelator

increases_activity of

in pancreas, in pancreatic beta cells