General Information:

Id: 4,140 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Cheng K et al.(2010) Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets J. Clin. Invest. 120: 2171-2183 [PMID: 20440072]

Interaction Information:

Comment The effect of adding iron in the form of ferric citrate was studied. At high doses, there was obvious cell death. At lower doses, there were significant decreases in Hif1a, Hnf4a, Glut1, and Glut2 expression. There was also significantly impaired glucose-stimulated insulin secretion (GSIS), with only a nonsignificant 13% increase, following high glucose in iron-treated cells.
Formal Description
Interaction-ID: 42724

drug/chemical compound

Iron

decreases_expression of

gene/protein

HIF1A

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for HIF1A
Comment The effect of adding iron in the form of ferric citrate was studied. At high doses, there was obvious cell death. At lower doses, there were significant decreases in Hif1a, Hnf4a, Glut1, and Glut2 expression. There was also significantly impaired glucose-stimulated insulin secretion (GSIS), with only a nonsignificant 13% increase, following high glucose in iron-treated cells.
Formal Description
Interaction-ID: 42725

drug/chemical compound

Iron

decreases_expression of

gene/protein

HNF4A

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for HNF4A
Comment The effect of adding iron in the form of ferric citrate was studied. At high doses, there was obvious cell death. At lower doses, there were significant decreases in Hif1a, Hnf4a, Glut1, and Glut2 expression. There was also significantly impaired glucose-stimulated insulin secretion (GSIS), with only a nonsignificant 13% increase, following high glucose in iron-treated cells.
Formal Description
Interaction-ID: 42726

drug/chemical compound

Iron

decreases_expression of

gene/protein

SLC2A1

in pancreas, in pancreatic beta cells
Comment The effect of adding iron in the form of ferric citrate was studied. At high doses, there was obvious cell death. At lower doses, there were significant decreases in Hif1a, Hnf4a, Glut1, and Glut2 expression. There was also significantly impaired glucose-stimulated insulin secretion (GSIS), with only a nonsignificant 13% increase, following high glucose in iron-treated cells.
Formal Description
Interaction-ID: 42727

drug/chemical compound

Iron

decreases_expression of

gene/protein

SLC2A2

in pancreas, in pancreatic beta cells
Drugbank entries Show/Hide entries for SLC2A2
Comment The effect of adding iron in the form of ferric citrate was studied. At high doses, there was obvious cell death. At lower doses, there were significant decreases in Hif1a, Hnf4a, Glut1, and Glut2 expression. There was also significantly impaired glucose-stimulated insulin secretion (GSIS), with only a nonsignificant 13% increase, following high glucose in iron-treated cells.
Formal Description
Interaction-ID: 42728

drug/chemical compound

Iron

decreases_activity of

in pancreas, in pancreatic beta cells