General Information:

Id: 413 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000298 COS-7 cell; BTO:0002181 HEK-293T cell; BTO:0000793 SH-SY5Y cell
article
Reference: Greggio E et al.(2006) Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. Neurobiol. Dis. 23: 329-341 [PMID: 16750377]

Interaction Information:

Comment PD related mutants Y1699C and R1441C of LRRK2 induce nuclear shrinkage 3-4 days after transfection. However the kinase-dead versions of the same mutants produced delayed cell death compared to the kinase-active forms.
Formal Description
Interaction-ID: 1817

gene/protein mutant

LRRK2-p.Y1699C

increases_activity of

process

neuron death

Comment PD related mutants Y1699C and R1441C of LRRK2 induce nuclear shrinkage 3-4 days after transfection. However the kinase-dead versions of the same mutants produced delayed cell death compared to the kinase-active forms.
Formal Description
Interaction-ID: 1818

gene/protein mutant

LRRK2-p.R1441C

increases_activity of

process

neuron death