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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	4,139 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Homo sapiens
Publication type:	article
Reference:	Cheng K et al.(2010) Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets J. Clin. Invest. 120: 2171-2183 [PMID: 20440072]

Interaction Information:

Comment	The effects of increasing HIF-1alpha via iron chelation with deferoxamine (DFO) upon cultured human islets was examined and compared with the effects of hypoxia. DFO caused dose-dependent increases in HNF4A, GLUT1, GLUT2, AKT2, and IRS2 mRNAs. In contrast, hypoxia increased GLUT1 but not GLUT2.
Formal Description Interaction-ID: 42707	process response to hypoxia NOT increases_expression of gene/protein SLC2A2 in pancreas, in pancreatic islet
Drugbank entries	Show/Hide entries for SLC2A2
Drugbank DB00428	Streptozocin ligand SLC2A2

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