General Information:

Id: 412 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
spinal cord embryonic explants
article
Reference: Mir M et al.(2009) Tumor necrosis factor alpha and interferon gamma cooperatively induce oxidative stress and motoneuron death in rat spinal cord embryonic explants Neuroscience 162: 959-971 [PMID: 19477238]

Interaction Information:

Comment Treatment of rat spinal cord embryonic explants with TNF-alpha increased GP91PHOX and COX-2 expression.
Formal Description
Interaction-ID: 1820

gene/protein

TNF

increases_quantity of

gene/protein

CYBB

Drugbank entries Show/Hide entries for TNF
Comment Treatment of rat spinal cord embryonic explants with TNF-alpha increased GP91PHOX and COX-2 expression.
Formal Description
Interaction-ID: 1821

gene/protein

TNF

increases_quantity of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for TNF or PTGS2
Comment Treatment of rat spinal cord embryonic explants with TNF-alpha induced apoptotic motoneuron death.
Formal Description
Interaction-ID: 1825

gene/protein

TNF

increases_activity of

phenotype

motor neuron degeneration

Drugbank entries Show/Hide entries for TNF
Comment TNF-alpha and IFN-gamma cooperate, via the transcription factor NF-kappa-B, to increase the expression of oxidative stress-inducing enzymes.
Formal Description
Interaction-ID: 8720

gene/protein

TNF

affects_activity of

process

I-kappaB kinase/NF-kappaB signaling

Drugbank entries Show/Hide entries for TNF