General Information:

Id: 4,129 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
article
Reference: De Vos P et al.(1996) Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma J. Clin. Invest. 98: 1004-1009 [PMID: 8770873]

Interaction Information:

Comment Treatment of rats with the PPARalpha activator fenofibrate did not change adipose tissue and body weight and had no significant effect on ob mRNA levels. However, administration of the thiazolidinedione BRL49653, a PPARgamma ligand, increased food intake and adipose tissue weight while reducing ob mRNA levels in rats in a dose-dependent manner.
Formal Description
Interaction-ID: 42554

gene/protein

PPARA

NOT affects_quantity of

tissue/cell line

adipose tissue

Drugbank entries Show/Hide entries for PPARA
Comment Treatment of rats with the PPARalpha activator fenofibrate did not change adipose tissue and body weight and had no significant effect on ob mRNA levels. However, administration of the thiazolidinedione BRL49653, a PPARgamma ligand, increased food intake and adipose tissue weight while reducing ob mRNA levels in rats in a dose-dependent manner.
Formal Description
Interaction-ID: 42555

gene/protein

PPARA

NOT affects_expression of

gene/protein

LEP

Drugbank entries Show/Hide entries for PPARA