General Information:

Id: 4,127 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
ob/ob mouse
article
Reference: Pfaffly J et al.(2010) Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice Synapse 64: 503-510 [PMID: 20175225]

Interaction Information:

Comment Basal striatal D2R binding (measured with autoradiography [(3)H] spiperone) did not differ between ob/ob and wild-type mice but the response to leptin did. In wild-type mice, leptin decreased striatal D2R binding, whereas, in ob/ob mice, leptin increased D2R binding. These findings provide further evidence that leptin modulates D2R expression in striatum and that these effects are genotype/phenotype dependent.
Formal Description
Interaction-ID: 42533

gene/protein

LEP

decreases_activity of

gene/protein

DRD2

in striatum; in wild-type mouse
Drugbank entries Show/Hide entries for DRD2
Comment Basal striatal D2R binding (measured with autoradiography [(3)H] spiperone) did not differ between ob/ob and wild-type mice but the response to leptin did. In wild-type mice, leptin decreased striatal D2R binding, whereas, in ob/ob mice, leptin increased D2R binding. These findings provide further evidence that leptin modulates D2R expression in striatum and that these effects are genotype/phenotype dependent.
Formal Description
Interaction-ID: 42534

gene/protein

LEP

increases_activity of

gene/protein

DRD2

in striatum; in ob/ob mouse
Drugbank entries Show/Hide entries for DRD2
Comment Basal striatal D2R binding (measured with autoradiography [(3)H] spiperone) did not differ between ob/ob and wild-type mice but the response to leptin did. In wild-type mice, leptin decreased striatal D2R binding, whereas, in ob/ob mice, leptin increased D2R binding. These findings provide further evidence that leptin modulates D2R expression in striatum and that these effects are genotype/phenotype dependent.
Formal Description
Interaction-ID: 42535

gene/protein

LEP

affects_expression of

gene/protein

DRD2

in striatum
Drugbank entries Show/Hide entries for DRD2