General Information:

Id: 407 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Rattus norvegicus
male
adenoviral construct to overexpress hepatic GPAT1 (Ad-GPAT1)
article
Reference: Nagle CA et al.(2007) Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance J. Biol. Chem. 282 [PMID: 17389595]

Interaction Information:

Comment Ad-GPAT1-treated rats had 50% lower hepatic NF-kappa-B activity and no difference in expression of tumor necrosis factor-alpha and interleukin-beta, consistent with hepatic insulin resistance in the absence of increased hepatic inflammation.
Formal Description
Interaction-ID: 1793

gene/protein

GPAM

NOT affects_expression of

gene/protein

TNF

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